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A Study to Evaluate the Effects of HSK3486 Administration on Cardiac Repolarization in Healthy Subjects

ClinicalTrials.gov ID NCT06379867
Sponsor Haisco Pharmaceutical Group Co., Ltd.
Information provided by Haisco Pharmaceutical Group Co., Ltd. (Responsible Party)
Last Update Posted 2024-04-26
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Study Overview

Brief Summary
Assess the effects of a single IV bolus of HSK3486 single dose on cardiac repolarization for healthy subjects.
Official Title
A Randomized, Positive and Placebo-Controlled Study to Evaluate the Effects of HSK3486 Administration on Cardiac Repolarization in Healthy Subjects
Conditions
Anesthesia
Intervention / Treatment
  • Drug: HSK3486
  • Drug: Placebo
  • Drug: Moxifloxacin
  • Drug: HSK3486
  • Drug: Placebo
  • Drug: Moxifloxacin
Other Study ID Numbers
  • HSK3486-112
Study Start (Actual)
2024-04-07
Primary Completion (Estimated)
2024-05-30
Study Completion (Estimated)
2024-08-30
Enrollment (Estimated)
48
Study Type
Interventional
Phase
Phase 1

Contacts and Locations

This section provides contact details for people who can answer questions about joining this study, and information on where this study is taking place.

To learn more, please see the Contacts and Locations section in How to Read a Study Record(https://clinicaltrials.gov/study-basics/how-to-read-study-record#contacts-and-locations).

Study Contact

Name: Chen Meixia

Phone Number: 67258779 ext 028

Email: chenmeixia@haisco.com

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies(https://clinicaltrials.gov/study-basics/learn-about-studies).
Eligibility Criteria
Description

Inclusion Criteria:

  1. Ability to understand and comply with protocol requirements and is willing voluntarily sign written ICF.
  2. Healthy participants at age from 18 to 45 years old (inclusive) at Screening.
  3. Male body weight ≥50 kg, female body weight ≥45 kg, with a body mass index BMI of 19~28 kg/m2 (inclusive).
  4. Left Ventricular Ejection Fraction (LVEF)≥50%.

Exclusion Criteria:

  1. Past or present clinically significant systemic disease as judged by the Investigator including, but not limited to psychiatric, neurologic, pulmonary, respiratory, cardiac, gastrointestinal, genitourinary, renal, hepatic, metabolic, endocrinologic, hematological, or autoimmune disorders.
  2. History of allergy to egg or egg products, soybean or soy products.
  3. History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance. History of allergy to HSK3486 or moxifloxacin or its investigational product excipients, or history of specific allergies (asthma, urticaria, eczema, etc.), or history of tendinitis or tendon rupture due to moxifloxacin or any other quinolone drug.
  4. Clinically significant infection/injury/disease within 1 month prior to dosing.
  5. Current or recent (< 6 months from screening) hepatobiliary disease.
  6. Current or past history of seizure disorder, including alcohol- or stimulant-related seizure, febrile seizure, or significant family history of idiopathic seizure disorder.
  7. Family history of sudden death at <50 years of age.
  8. History of unexplained loss of consciousness, unexplained syncope, unexplained irregular heartbeats or palpitations, clinically significant head injury.
  9. Pre-existing condition interfering with normal gastrointestinal anatomy or motility, hepatic and/or renal function, or conditions that could interfere with the absorption, metabolism, and/or excretion of study drug (e.g., history of bariatric surgery or intestinal bypass surgery; simple uncomplicated appendectomies and hernia repairs are allowed, but cholecystectomy is not allowed).
  10. Positive test results for hepatitis B surface antigen, hepatitis C antibody, treponema pallidum antibody, human immunodeficiency virus (HIV) antigen/antibody combination test.
  11. Subjects with previous or suspected difficult airway (e.g., modified Mallampti score III-IV, congenital microglossia, mandibular dysplasia), or respiratory insufficiency, history of obstructive pulmonary disease, history of asthma, sleep apnea syndrome; history of failed tracheal intubation; history of bronchospasm requiring treatment within 3 months prior to screening; acute respiratory infection, and with obvious symptoms such as fever, wheezing, nasal congestion or cough within 1 week prior to baseline.
  12. Knowledge of any kind of cardiovascular disorder/condition/procedure known to increase the possibility of QT prolongation or history of risk factors for TdP (e.g., heart failure, hypokalemia, hypomagnesemia, congenital Long QT syndrome, or family history of Long QT Syndrome.
  13. Laboratory tests at screening or baseline judged clinically significant by the investigator, including, but not limited to, ALT or AST > 1.2 ×ULN (the upper limit of the reference range at screening or baseline), direct bilirubin > ULN (congenital nonhemolytic hyperbilirubinemia [e.g., suspicion of Gilbert's syndrome based on total and direct bilirubin] is not acceptable), creatine kinase (CK) > ULN (one repeat test allowed), thyroid stimulating hormone (TSH) outside normal range (0.75 to 5.6 mIU/L) , serum potassium outside normal range (3.5 to 5.3 mmol/L).
  14. Rest sitting vital sign results abnormal and clinically significant at screening or baseline, ear temperature outside normal range, diastolic blood pressure ≥ 90 mmHg or systolic blood pressure ≥ 140 mmHg, HR < 55 beats/min or > 100 beats/min (test can be repeated once according to investigator's judgment).
  15. Oxygen saturation (SpO2) below 95% at baseline.
  16. Abnormal 12-lead ECG at screening or baseline (any test abnormality), including any of the following:

    1. QTcF > 450 ms
    2. QRS > 110 ms
    3. PR > 200 ms
    4. Second or third-degree AV block
    5. Any rhythm other than sinus rhythm of clinical significance.
  17. Estimated Glomerular Filtration Rate (eGFR) < 90 mL/min (estimated using MDRD equation).
  18. Participation in another clinical study of an investigational drug (or medical device) within 3 months (or 5 half-lives, whichever is longer) prior to dosing, or previous participation in any other clinical trial related to HSK3486.
  19. Donation of blood within 3 months prior to screening, plasma within 2 weeks prior to screening, platelets within 6 weeks prior to screening, or receive blood products within 2 months prior to admission to a the investigational site.
  20. Sperm and egg donation program from screening period to 90 days after study end.
  21. Pregnant or lactating women or those with positive pregnancy test results. Male or female subjects of childbearing potential do not agree to use an effective method of contraception from the time of signing ICF until 90 days after leaving the investigational site after the last dose (see Appendix 6 for details of specific contraceptive methods).
  22. Use or intend to use any medications/products known to alter drug absorption, metabolism, or elimination processes, including St. John's wort, within 30 days prior to dosing or during the clinical trial.
  23. Use or intend to use of any prescription, nonprescription, vitamin, herbal, or nutraceutical within 14 days prior to dosing or during the clinical trial.
  24. Smoking (≥ 5 cigarettes per day) within 6 months prior to screening, or inability to quit smoking during the trial.
  25. Positive alcohol breath test, or regular drinking within 6 months prior to dosing or during the trial, i.e. drinking more than 21 units (men) or 14 units (women) of alcohol per week (1 unit =360 mL beer or 45 mL spirits or 150 mL wine at 40% alcohol).
  26. Positive urine drug abuse screening (morphine, tetrahydrocannabinol, methamphetamine, methylenedioxyamphetamine, ketamine), or history of drug abuse, drug dependence within 6 months prior to screening, or drug use within 3 months prior to screening.
  27. Subjects who tested positive for COVID-19 during screening.
  28. Eating fruits or foods affecting metabolic enzymes, such as grapefruit (citrus), pomelo, etc., within 7 days prior to screening; and not abstaining from the above beverages, fruits or foods during the study period.
  29. Previous chronic excessive consumption (more than 8 cups per day, 1 cup =250 mL) of tea, coffee or caffeinated beverages, or intake of caffeine and/or purine-rich foods or beverages (e.g. coffee, tea, chocolate, caffeinated carbonated beverages, cola, etc.) within 48 hours prior to screening, or refusal to stop drinking tea, coffee and/or caffeinated beverages during the trial.
  30. Performing or unwilling to refrain from strenuous physical activity, which could cause muscle aches or injury, including contact sports, at any time from 3 days prior to dosing through the end-of-study visit.
  31. Subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical disease (e.g., infectious disease).
  32. Any condition or situation that, in the opinion of the investigator, would prevent proper evaluation of the safety or efficacy of the study drug according to the study protocol (e.g., poorly compliant subject, poorly vascular condition, allergies to medical plastics/latex).
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Ages Eligible for Study
18 Years to 45 Years (Adult )
Sexes Eligible for Study
All
Accepts Healthy Volunteers
Yes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

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Design Details
Primary Purpose : Treatment
Allocation : Randomized
Interventional Model : Crossover Assignment
Masking : Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)

Arms and Interventions

Participant Group/Arm Intervention/Treatment
Participant Group/Arm Experimental: HSK3486 Intervention/Treatment Drug: HSK3486
  • 0.4 mg/kg, IV bolus administration

  • Other Names:
    • Ciprofol
Participant Group/Arm Placebo Comparator: Placebo Intervention/Treatment Drug: Placebo
  • IV bolus administration

Participant Group/Arm Active Comparator: Moxifloxacin Intervention/Treatment Drug: Moxifloxacin
  • 0.4 g, Oral administration with 240 mL

Primary Outcome Measures
Outcome Measure Measure Description Time Frame
ΔQTcIThe change-from-baseline in QTc interval, corrected for HR using the individual QT correction method (QTcI).Pre-dose and at multiple timepoints post-dose on Days 1 to 2 in each period.
Secondary Outcome Measures
Outcome Measure Measure Description Time Frame
ΔHR, ΔQTcF, ΔPR, and ΔQRSChange-from-baseline HR, QTcF, PR, and QRS intervals, which will be used as the dependent variable for calculation of model-derived ΔΔHR, ΔΔQTcF, ΔΔPR, and ΔΔQRS for the by-time point analysis, respectively.Pre-dose and at multiple timepoints post-dose on Days 1 to 2 in each period.
Categorical outliers for QTcI, QTcF, HR, PR, and QRS intervalsCategorical outliers for QTcI, QTcF, HR, PR, and QRS intervals.Pre-dose and at multiple timepoints post-dose on Days 1 to 2 in each period.
AE and SAEIncidence of AE and SAEUp to Day 18
CmaxMaximum Observed Plasma ConcentrationPre-dose and at multiple timepoints post-dose on Days 1 to 2 in each period
AUClastArea Under the Plasma Concentration-Time Curve From Time Zero to Time of Last Quantifiable Concentration of HSK3486Pre-dose and at multiple timepoints post-dose on Days 1 to 2 in each period
t1/2Elimination Half-LifePre-dose and at multiple timepoints post-dose on Days 1 to 2 in each period

Collaborators and Investigators

This is where you will find people and organizations involved with this study.
Sponsor
Haisco Pharmaceutical Group Co., Ltd.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Registration Dates
First Submitted
2024-04-18
First Submitted that Met QC Criteria
2024-04-18
First Posted
2024-04-23
Study Record Updates
Last Update Submitted that met QC Criteria
2024-04-24
Last Update Posted
2024-04-26
Last Verified
2024-04

More Information

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Additional Relevant MeSH Terms