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Ghrelin Levels in Pancreatic Cancer Patients

This study has been completed.
Information provided by (Responsible Party):
Dartmouth-Hitchcock Medical Center Identifier:
First received: September 22, 2005
Last updated: October 12, 2015
Last verified: August 2015
The primary outcome measure for this study is plasma ghrelin level.

Condition Intervention
Pancreatic Cancer
Procedure: Blood draw

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Assessment of Plasma Ghrelin Levels in Patients With Pancreatic Cancer

Resource links provided by NLM:

Further study details as provided by Dartmouth-Hitchcock Medical Center:

Primary Outcome Measures:
  • To evaluate plasma ghrelin levels in patients with pancreatic cancer and compare with age matched controls [ Time Frame: prior to treatment ]

Secondary Outcome Measures:
  • To investigate the role of ghrelin in pathophysiology of cancer cachexia [ Time Frame: prior to treatment ]
  • To generate hypotheses for future studies and treatment based on the findings [ Time Frame: prior to treatment ]

Biospecimen Retention:   Samples Without DNA
Whole Blood

Enrollment: 72
Study Start Date: April 2004
Study Completion Date: September 2015
Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Pancreatic cancer patients
Procedure: Blood draw
One blood draw prior to first treatment
Healthy controls
Procedure: Blood draw
One blood draw prior to first treatment

Detailed Description:

The primary outcome measure for this study is plasma ghrelin level, and the two primary comparison are:

  • Patients with cachexia versus patients without cachexia
  • Patients with cachexia versus healthy controls

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Pancreatic cancer patients who have not received treatment. Healthy age-matched controls.

Inclusion Criteria:

  • Histological or cytological proof of pancreatic adenocarcinoma
  • The control are will include healthy age-matched patients without cancer
  • The test arm will include patients with pancreatic cancer and they will divided into two groups: those with and without weight loss
  • Patients must have recovered from any major infections and/or surgical procedures

Exclusion Criteria:

  • Patients with other serious medical illness like congestive heart failure, thyroid disease,liver disease or renal failure - conditions that will alter their nutritional state
  • Patients on appetite stimulant and those receiving total parenteral nutrition
  • Patients who have undergone gastrectomy or those who have gastric ulcers
  • Patients receiving active chemotherapy
  • No prior malignancy except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer or for which patient has been disease free for at least five years.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00225745

United States, New Hampshire
Dartmouth Hitchcock Medical Center/Norris Cotton Cancer Center
Lebanon, New Hampshire, United States, 03756
Sponsors and Collaborators
Dartmouth-Hitchcock Medical Center
Principal Investigator: J Marc Pipas, MD Dartmouth-Hitchcock Medical Center
  More Information

Responsible Party: Dartmouth-Hitchcock Medical Center Identifier: NCT00225745     History of Changes
Other Study ID Numbers: DMS 0405
Study First Received: September 22, 2005
Last Updated: October 12, 2015

Keywords provided by Dartmouth-Hitchcock Medical Center:

Additional relevant MeSH terms:
Pancreatic Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Endocrine Gland Neoplasms
Digestive System Diseases
Pancreatic Diseases
Endocrine System Diseases processed this record on May 25, 2017