Epidemiology and Control of Mansonella Perstans Infection in Uganda

This study has been completed.
Ministry of Health, Uganda
Information provided by:
DBL -Institute for Health Research and Development
ClinicalTrials.gov Identifier:
First received: September 21, 2005
Last updated: April 19, 2007
Last verified: April 2007
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.

Condition Intervention
Abdominal Pains
Drug: ivermectin and albendazole

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda

Resource links provided by NLM:

Further study details as provided by DBL -Institute for Health Research and Development:

Primary Outcome Measures:
  • microfilariae periodicity patterns
  • epidemiology of M. perstans at community level
  • clinical spectre among infected
  • reduction in microfilaraemia

Secondary Outcome Measures:
  • treatment effect on clinical manifestations

Estimated Enrollment: 1000
Study Start Date: November 2005
Estimated Study Completion Date: February 2006
Detailed Description:

Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control

Specific objectives:

  1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans
  2. To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity
  3. To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.

Ages Eligible for Study:   5 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Individuals >= 5 years with or without M. perstans infection

Exclusion Criteria:

  • Individuals < 5 years
  • Pregnant women
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00215280

Luwero and Mukono, Luwero and Mukono Districts, Uganda
Sponsors and Collaborators
DBL -Institute for Health Research and Development
Ministry of Health, Uganda
Principal Investigator: Asanta M Asio, Msc Ministry of Health, Uganda
  More Information

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00215280     History of Changes
Other Study ID Numbers: MV917090205 
Study First Received: September 21, 2005
Last Updated: April 19, 2007
Health Authority: Uganda: National Council for Science and Technology

Keywords provided by DBL -Institute for Health Research and Development:
Mansonella perstans

Additional relevant MeSH terms:
Abdominal Pain
Dipetalonema Infections
Lymphatic Diseases
Nematode Infections
Parasitic Diseases
Secernentea Infections
Signs and Symptoms
Signs and Symptoms, Digestive
Spirurida Infections
Anti-Infective Agents
Anticestodal Agents
Antimitotic Agents
Antineoplastic Agents
Antiparasitic Agents
Antiplatyhelmintic Agents
Antiprotozoal Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Therapeutic Uses
Tubulin Modulators

ClinicalTrials.gov processed this record on May 02, 2016