We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Epidemiology and Control of Mansonella Perstans Infection in Uganda

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00215280
First Posted: September 22, 2005
Last Update Posted: April 20, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Ministry of Health, Uganda
Information provided by:
DBL -Institute for Health Research and Development
  Purpose
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.

Condition Intervention
Mansonelliasis Pruritus Lymphoedema Abdominal Pains Drug: ivermectin and albendazole

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda

Resource links provided by NLM:


Further study details as provided by DBL -Institute for Health Research and Development:

Primary Outcome Measures:
  • microfilariae periodicity patterns
  • epidemiology of M. perstans at community level
  • clinical spectre among infected
  • reduction in microfilaraemia

Secondary Outcome Measures:
  • treatment effect on clinical manifestations

Estimated Enrollment: 1000
Study Start Date: November 2005
Estimated Study Completion Date: February 2006
Detailed Description:

Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control

Specific objectives:

  1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans
  2. To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity
  3. To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   5 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Individuals >= 5 years with or without M. perstans infection

Exclusion Criteria:

  • Individuals < 5 years
  • Pregnant women
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00215280


Locations
Uganda
Luwero
Luwero and Mukono, Luwero and Mukono Districts, Uganda
Sponsors and Collaborators
DBL -Institute for Health Research and Development
Ministry of Health, Uganda
Investigators
Principal Investigator: Asanta M Asio, Msc Ministry of Health, Uganda
  More Information

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00215280     History of Changes
Other Study ID Numbers: MV917090205
First Submitted: September 21, 2005
First Posted: September 22, 2005
Last Update Posted: April 20, 2007
Last Verified: April 2007

Keywords provided by DBL -Institute for Health Research and Development:
Mansonella perstans
microfilaraemia
ivermectin
albendazole
Uganda

Additional relevant MeSH terms:
Lymphedema
Abdominal Pain
Pruritus
Dipetalonema Infections
Acanthocheilonemiasis
Mansonelliasis
Lymphatic Diseases
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Signs and Symptoms, Digestive
Skin Diseases
Skin Manifestations
Filariasis
Spirurida Infections
Secernentea Infections
Nematode Infections
Helminthiasis
Parasitic Diseases
Albendazole
Ivermectin
Anthelmintics
Antiparasitic Agents
Anti-Infective Agents
Anticestodal Agents
Antiplatyhelmintic Agents
Antiprotozoal Agents
Tubulin Modulators
Antimitotic Agents