Factors Associated With Success of NIPPV in ALS Patients
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This is a retrospective cohort study to assess the factor associated with success of non-invasive positive ventilation in ALS patients.
Condition or disease
Patients with ALS who were admitted to a tertiary hospital for initially applying non-invasive positive pressure ventilation (NIPPV). The objective of this study was to investigate factors associated with optimal NIPPV initiation and adherence, and to assess the long-term effects of NIPPV adherence in ALS patients.
Success of NIPPV [ Time Frame: through intervention completion, with an average of 10 days ]
The success of NIPPV application was defined empirically as use of ≥ 2 hours per day and the failure as use of < 2 hours for a day or conversion to invasive positive pressure ventilation via tracheostomy or refuse to apply NIPPV during hospitalization.
Secondary Outcome Measures :
Lenght of stay [ Time Frame: through intervention completion, with an average of 10 days ]
The length of stay (LOS) was defined as the interval between admission and hospital discharge, and calculated as the number of midnights between admission and discharge from the hospital.
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Layout table for eligibility information
Ages Eligible for Study:
19 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
ALS patients who were admitted for applying non-invasive positive pressure ventilation initially.
Patients fulfilling the El Escorial World Federation criteria for probable, or definite ALS
Aged ≥ 19 years
Patients who performed blood gas analysis including venous blood gas and arterial blood gas before NIPPV application.
Patients who had experience in applying the NIPPV or currently using NIPPV
Patients who applied in outpatient settings
Patients who did not perform blood gas analysis before NIPPV application
Patietns who had a history of asthma or COPD,
Patients who didn't have any record of NIPPV application time