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A Study of KN046 in Patients With Thymic Carcinoma Who Failed Immune Checkpoint Inhibitors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04925947
Recruitment Status : Not yet recruiting
First Posted : June 14, 2021
Last Update Posted : August 18, 2021
Sponsor:
Collaborator:
Jiangsu HengRui Medicine Co., Ltd.
Information provided by (Responsible Party):
Weill Medical College of Cornell University

Brief Summary:
This study will assess the safety and efficacy of the study drug KN046 in patients with advanced thymic carcinoma who progressed after prior treatment with immune checkpoint inhibitor therapy.

Condition or disease Intervention/treatment Phase
Thymic Carcinoma Drug: KN046 Phase 2

Detailed Description:

Patients will receive KN046 intravenously at 5 mg/kg every 2 weeks until progression or excessive toxicity for up to to two years, with the goal of this trial to contribute to the development of active and well tolerated treatments for patients who have progressed on prior treatment therapies.

Recently, molecules that combine PD-1 and CTLA-4 have been developed for patients with lung cancer, with the hope that targeted therapy will be more effective than standard of care therapies. KN046 is believed to be less toxic than other targeted therapies with an assumption that the whole molecule can actively target tumor tissue for a much higher affinity of the anti-PD-L1 portion and a weaker affinity for anti-CTLA-4, leading to less autoimmune disorders and toxicities for patients than seen with other targeted therapies.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 29 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase II Study of KN046 in Patients With Thymic Carcinoma Who Failed Immune Checkpoint Inhibitors
Estimated Study Start Date : September 30, 2021
Estimated Primary Completion Date : July 31, 2024
Estimated Study Completion Date : July 31, 2026

Arm Intervention/treatment
Experimental: KN046
KN046 will be given intravenously every 2 weeks.
Drug: KN046
KN046 will be given intravenously at 5 mg/kg every 2 weeks. A cycle is defined as 2 treatments (28 days). Treatment will be given until progression, excessive toxicity, or up to two years.




Primary Outcome Measures :
  1. Anti-tumor activity of KN046 in subjects with thymic carcinoma, determined by subject disease response rate defined by the RECIST 1.1 criteria. [ Time Frame: Through study completion (an average of 2 years) ]
    Disease response rate


Secondary Outcome Measures :
  1. Safety of KN046 in subjects with thymic carcinoma, measured by the number of adverse events that occur in subjects while receiving study treatment. [ Time Frame: Through study completion (an average of 2 years) ]
  2. Tolerability of KN046 in subjects with thymic carcinoma, measured by the severity of adverse events that occur in subjects while receiving study treatment, assessed using the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. [ Time Frame: Through study completion (an average of 2 years) ]
  3. Duration of response for KN046 in subjects with thymic carcinoma, determined by subject disease response rate defined by the RECIST 1.1 criteria. [ Time Frame: From first documented response (PR or CR) to the date of first documented disease progression or death due to underlying cancer (an average of 2 years) ]
  4. Progression Free Survival (PFS) for KN046 in subjects with thymic carcinoma, determined by subject disease response rate defined by the RECIST 1.1 criteria. [ Time Frame: From start of treatment to time of progression (an average of 2 years) ]
  5. Overall Survival (OS) for KN046 in subjects with thymic carcinoma, determined by subject disease response rate defined by the RECIST 1.1 criteria. [ Time Frame: From baseline to death due to underlying cancer (on average 30 months) ]
    In previous studies, OS has not been reached. However OS rates for 6 and 9 months were 74.3% and 65.2%, respectively.



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Signed informed consent form.
  • Male or female, 18 years of age or older; willing and able to complete all required procedures of study.
  • Pathologically confirmed diagnosis of thymic carcinoma; a tumor sample is required for confirmation of pathological diagnosis and further studies on the tumor tissue.
  • Inoperable or metastatic disease.
  • Progressive disease documented in the last 6 months.
  • Has failed platinum-based chemotherapy, with progression either during or after treatment.
  • Had failed at least one regimen of systemic therapy containing immune checkpoint blockade therapy targeting PD-1, PD-L1, or CTLA-4 for locally advanced unresectable or metastatic disease. Subjects should have documented progressive disease while or after an immune checkpoint therapy. If subjects discontinued therapy due to reasons other than progressive disease, subjects should have completed at least 2 cycles of immune checkpoint therapy.
  • Baseline measurable disease according to RECIST 1.1. Target lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.
  • ECOG performance status of 0 or 1.
  • Adequate organ function assessed within 7 days prior to first trial treatment:

Hematological function:

ANC≥1.5 x 109/L; Hemoglobin≥9 g/dL; Platelets≥100 x 109/L

Renal function:

Calculated creatinine clearance≥60 mL/min (Cockcroft-Gault method)

Hepatic function:

Total bilirubin≤1.5 x ULN (or 2.5 x ULN for documented Gilberts' syndrome); ALT/AST≤3.0 x ULN (or 5.0 x ULN for documented liver metastasis); INR or aPTT ≤1.5 x ULN

  • Have a life expectancy of at least 3 months.
  • If female of childbearing potential, have a negative serum pregnancy test within 7 days prior to first trial treatment.
  • If female of childbearing potential or a male subject with a partner with childbearing potential, be willing to use a highly effective method of contraception (with a failure rate of less than 1.0% per year) from first study treatment to 24 weeks after completion of the trial treatment.

Exclusion Criteria:

  • Thymomas, thymolipoma, germ cell tumors, teratomas, seminomas.
  • Leptomeningeal metastasis or untreated active CNS metastasis or leptomeningeal metastasis. Subjects with CNS metastasis may be eligible provided they are treated and clinically stable for at least 4 weeks and have no evidence of new or enlarging brain metastases and also are off steroids 7 days prior to first trial treatment.
  • Is currently participating and receiving an investigational drug or has participated in a study of an investigational drug within 4 weeks or within 5 times of half-life (no less than 2 weeks), whichever is shorter, prior to the first dose of trial treatment.
  • Major surgery for any reason, except diagnostic biopsy, within 4 weeks of the first administration of trial treatment and/or if the subject has not fully recovered from the surgery within 4 weeks of the first administration of trial treatment.
  • Radiation within 4 weeks prior to the first administration of trial treatment; palliative radiation will be allowed if more than 2 weeks before start of KN046 treatment.
  • Subjects receiving immunosuppressive agents (such as systemic steroids); topical use of steroids and steroid inhalers are allowed. Replacement therapy because of adrenal insufficiency is also allowed.
  • Vaccination within 28 days of the first administration of trial treatment, except for administration of inactivated vaccines (e.g., inactivated influenza vaccines).
  • Has interstitial lung disease, or a history of pneumonitis that required oral or intravenous glucocorticoids to assist with management.
  • History or current active autoimmune disease that might deteriorate when receiving an immunostimulatory agent, including but not limited to:

Myasthenia gravis (MG), Good syndromes, ISAACS syndromes, polymyositis, myocarditis, neuromuscular syndrome (myotonic dystrophy myositis, Eaton-Lambert syndrome), blood disorders (red cell aplasia, hypogammaglobulinemia, T-cell deficiency syndrome, erythrocytosis, pancytopenia, megakaryocytopenia, T-cell lymphocytosis, pernicious anemia), systemic lupus erythematosus, sarcoidosis, scleroderma, Crohn's disease, inflammatory bowel disease, Wegener syndrome (granulomatosis with polyangitis, Grave's disease, rheumatoid arthritis, hypophysitis, uveitis), autoimmune hepatitis, systemic sclerosis (for example scleroderma), Hashimoto thyroiditis (with the exception as stated below), hyperparathyroidism, stiff-person syndrome, Addison disease, panhypopituitarism, autoimmune vasculitis, autoimmune neuropathy (Guillain-Barre syndrome) etc.

NOTE: Subjects with Type I diabetes, vitiligo, psoriasis, hypo- or hyperthyroid disease, Sjögren syndrome not requiring immunosuppressive treatment are eligible. Subjects requiring hormone replacement with corticosteroids are eligible if the steroids are administered only for the purpose of hormonal replacement and at doses ≤10 mg or equivalent prednisone per day. Administration of steroids for other conditions through a route known to result in a minimal systemic exposure (topical, intranasal, intra-ocular, or inhalation) are acceptable.

  • Previous malignant disease other than the target malignancy to be investigated in this study with the exception of adequately treated non-melanomatous cancers of the skin, in situ carcinoma of the prostate/cervical/breast cancer, or other malignancy treated at least 5 years previously with surgery and/or curative radiotherapy, and there is no evidence of recurrence since that time.
  • History of uncontrolled intercurrent illness including but not limited to: Active HBV or HCV infection (If HBsAg and HCV antibody positive, HBV DNA and HCV RNA assay should be performed. Subjects may be eligible if HBV DNA ≤ 500 UI/ml (or 2000 copies/ml) or HCV RNA negative); Known HIV infection or known history of acquired immune deficiency syndrome (AIDS); Active tuberculosis infection; Active infection within 2 weeks prior to the first dose of trial treatment that require the use of systemic antibiotics; Hypertension uncontrolled by standard therapies (not stabilized to 150/90 mmHg); Clinically significant (that is, active) cardiovascular disease: cerebral vascular accident/stroke (< 6 months prior to enrolment), myocardial infarction (< 6 months prior to enrolment), unstable angina pectoris, congestive heart failure (New York Heart Association Classification Class II-IV) or serious cardiac arrhythmia requiring medication (including corrected QT interval prolongation of > 470 msec calculated according to Fridericia and/or pacemaker or prior diagnosis of congenital long QT syndrome
  • Persisting toxicity related to prior therapy (including any prior investigational therapy) of CTCAE ≥ grade 2 (NCI-CTCAE v5.0) or related toxicity not recovery to baseline, with the exception of alopecia of any grade.
  • Prior allo-HSCT or solid organ transplant.
  • Known severe hypersensitivity reactions to antibody drug (≥ grade 3 NCI-CTCAE v5.0), any history of anaphylaxis, uncontrolled asthma (that is, 3 or more features of partially controlled asthma), or any history of severe drug hypersensitivity (for example immune mediated liver toxicity, immune mediated thrombocytopenia or anemia).
  • Is pregnant or breastfeeding.
  • Other medical conditions that at the discretion of investigator interfere with the requirements of the trial in terms of safety or efficacy evaluation, or treatment compliance. These include but are not limited to psychiatric or substance abuse disorder, moderate to large pleural fluid/cardiac effusion/ascites, or recurrent/refractory pleural fluid/cardiac effusion/ascites.
  • .Subjects with history or baseline positive antiacetylcholine receptor (AChR) autoantibody and anti-MuSK autoantibody.
  • Subjects who developed grade 3 or above immune related AE which could not be managed by steroid or immune suppressant will be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04925947


Contacts
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Contact: Victoria Dai, RN 212-746-2225 vid9053@med.cornell.edu
Contact: Giuseppe Giaccone, MD 646-962-4969 gig4001@med.cornell.edu

Locations
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United States, New York
Weill Cornell Medicine
New York, New York, United States, 10065
Contact: Giuseppe Giaccone, MD    646-962-4969    gig4001@med.cornell.edu   
Sponsors and Collaborators
Weill Medical College of Cornell University
Jiangsu HengRui Medicine Co., Ltd.
Investigators
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Principal Investigator: Giuseppe Giaccone, MD Weill Medical College of Cornell University
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Responsible Party: Weill Medical College of Cornell University
ClinicalTrials.gov Identifier: NCT04925947    
Other Study ID Numbers: 20-08022493
First Posted: June 14, 2021    Key Record Dates
Last Update Posted: August 18, 2021
Last Verified: August 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Carcinoma
Thymoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Complex and Mixed
Thymus Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lymphatic Diseases