Enhancing Cognitive Control Abilities Using Mobile Technology in a Senior Living Community (Senior Living)
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|ClinicalTrials.gov Identifier: NCT04905849|
Recruitment Status : Active, not recruiting
First Posted : May 28, 2021
Last Update Posted : June 7, 2022
|Condition or disease||Intervention/treatment||Phase|
|Aging Cognitive Change||Behavioral: Adaptive Cognitive Control Trainer (ACCT) Behavioral: Active Control App||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||19 participants|
|Intervention Model:||Sequential Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Official Title:||Enhancing Cognitive Control Abilities Using Mobile Technology in a Senior Living Community|
|Actual Study Start Date :||May 1, 2021|
|Estimated Primary Completion Date :||September 2023|
|Estimated Study Completion Date :||December 2023|
Experimental: Adaptive Cognitive Control Trainer (ACCT)
There are three modules within the game, each training a different aspect of cognitive control (attention, goal management, working memory): a visual search task for attention abilities, a spatial span task for working memory, and a task switching paradigm for goal management abilities. There are also 3 different levels of difficulty associated with each module; advancing to the next level delivers an advanced challenge that enhances the difficulty in performing the given cognitive task. Participants advance to the next level of difficulty following 6 training sessions occurring over 2 weeks, with the total training experience being 6 weeks of training (3 days/week), with each training session lasting 36 minutes (not including self-paced breaks).
Behavioral: Adaptive Cognitive Control Trainer (ACCT)
Module 1: Attention=> This module demands an active scan of the screen in search for a target, much like traditional visual search tasks. Participants quickly identify the direction that a probe target is facing (up, down, left, right), and are aided by the presence of directional cue indicating where the location of the target will appear.
Module 2: Goal Management=> Requires participants to rapidly switch their focus based on distinct rules. Participants are presented with exemplar objects along with a target, and are asked to indicate which exemplar presented is most like the target.
Module 3: Working Memory=> Engages spatial working memory resources similar to the Corsi block task. Participants memorize the location of objects on screen followed by a 5-7 second delay period, with a correct response leading to a greater number of potential targets to be memorized on the next trial (and vice versa).
Active Comparator: Active Control Group
An active control application will be used for this arm. The total training experience here will also be for 6 weeks (3 days/week), with each training session lasting ~30 minutes (not including self-paced breaks). Here an app that is matched in terms of expectancy of benefits compared to our training groups will be determined by questioning 100 naïve individuals to predict their expected improvement on each cognitive domain across a multitude of possible applications.
Behavioral: Active Control App
The app used here is undergoing expectancy-matching at the present time, will be updated with the final app characteristics when completed out of a list of several possibilities
- Mean Change on Adaptive Cognitive Evaluation (ACE) from Baseline at 6 weeks [ Time Frame: At Baseline and post intervention at the 6 week mark ]ACE is a custom mobile cognitive health assessment battery that presents paradigms typically used in standard cognitive neuroscience laboratories. Here the investigators will assess a measure of (1) Attention (2) Working memory, and (3) Goal management in the ACE software. We will assess response time, accuracy, and response time variability in each case, with faster/more accurate/less variable performance being indicative of improved cognitive control.
- Mean Change on Everyday Cognition Scale (ECog) from Baseline at 6 weeks [ Time Frame: At Baseline and post intervention at the 6 week mark ]The Everyday Cognition Scale (ECog) measures the ability to perform everyday tasks that demand memory, language, visuospatial abilities, planning, organization, and divided attention. The ECog consists of a global and domain scores for each of the previously described categories, and is scored as follows: 1= better or no change compared to 10 years earlier, 2= questionable/occasionally worse compared to 10 years earlier, 3= consistently a little worse compared to 10 years earlier, 4= consistently much worse compared to 10 years earlier. Thus, the lower the overall score is on this measure at both the global and domain score level, the better one is performing with respect to their cognition.
- Mean Change on Cognitive Failures Questionnaire (CFQ) from Baseline at 6 weeks [ Time Frame: At Baseline and post intervention at the 6 week mark ]The Cognitive Failures Questionnaire (CFQ) assesses participant distractibility. The CFQ score ranges from 0 to 100, with the lower the overall score is on this measure, the better one is performing with respect to their cognition.
- Mean Change on General health and well-being (SF-36) from Baseline at 6 weeks [ Time Frame: At Baseline and post intervention at the 6 week mark ]The general health and well-being (SF-36) score assesses participant health. The SF-36 score ranges from 0 to 100. The higher the overall score is on this measure, the better one is performing with respect to their health and well-being.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04905849
|United States, California|
|UC San Francisco|
|San Francisco, California, United States, 94158|
|Principal Investigator:||Joaquin Anguera, Ph.D.||UC San Francisco|