A Study of EXP039 Treatment in Subjects With r/r NHL Subjects

Inclusion Criteria:

1. The patient volunteered to participate in the study and signed the Informed Consent;
2. Age between 18 and 70 (including 18 and 70), male or female;
3. Expected survival ≥ 12 weeks;
4. ECOG score 0-2
5. CD19 or CD20 positive B-NHL confirmed by cytology or histology according to WHO2016 criteria;
6. Patients with a clear diagnosis of relapsed and/or refractory B-NHL, including DLBCL, FL and MCL;
7. For CD20-positive subjects, they should have received at least one regimen containing anti-CD20-targeted therapy (such as rituximab). If they do not complete the regimen due to intolerance, the cause of intolerance should be recorded;
8. No contraindications of apheresis;
9. At least one measurable lesion according to Lugano 2014 criteria;
10. Adequate organ function.

Exclusion Criteria:

1. Malignant tumors other than B-NHL within 5 years prior to screening, except cervical carcinoma in situ, basal cell or squamous cell skin cancer, local prostate cancer after radical surgery, and breast ductal carcinoma in situ after radical surgery;
2. Active HIV, HBV, HCV or treponema pallidum infection ;
3. Any instability of systemic disease, including but not limited to active infection (except local infection), severe cardiac, liver, kidney, or metabolic disease need therapy;
4. Any uncontrolled, active disease that prevents participation in the trial;
5. Female subjects who have been pregnant or breastfeeding, or who plan to conceive during or within 1 year after treatment, or male subjects' partner plans to conceive within 1 year after their cell transfusion;
6. Active or uncontrolled infections requiring systemic treatment within 14 days before enrollment;
7. Patients who have been previously infected with tuberculosis;
8. Administered Corticosteroids and/or other immunosuppressants within 7 days before apheresis. and 5 days before the infusion of EXP039;
9. Patients with central nervous system involvement;
10. Any systemic antitumor therapy was performed within 2 weeks before conditional treatment chemotherapy pretreatment;
11. Prior use of any CAR-T cell product or other genetically modified T-cell therapy;