S. Aureus Translocation From Skin and Nose to Periprosthetic Tissues
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|ClinicalTrials.gov Identifier: NCT04666532|
Recruitment Status : Enrolling by invitation
First Posted : December 14, 2020
Last Update Posted : December 14, 2020
Surgical site infections (SSI) are a significant clinical issue that requires the use of a great amount of resources. In particular, periprosthetic joint infections (PJIs) have potentially catastrophic effects on patients' health-related quality of life, function, healthcare costs, outcomes and medical implications. National surveillance estimates may under-report the true incidence and when considering the large number of total hip (THA) and total knee arthroplasty (TKA) procedures performed each year.
Patients who have a high-level of nasal bacteria have been found to have a risk of surgical site infection that is three to six times the risk compared with noncarriers and low-level carriers. The association between a patient's nasal carriage of S. aureus, specifically MRSA, and PJI has been demonstrated in a systematic review and confirmed in recent cohort studies. While this association seems to be well accepted, no mechanistic explanation has been provided for this association.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||200 participants|
|Official Title:||Staphylococcus Aureus Translocation From Skin and Nose to Periprosthetic Tissues|
|Actual Study Start Date :||October 22, 2020|
|Estimated Primary Completion Date :||December 31, 2021|
|Estimated Study Completion Date :||December 31, 2021|
- S. aureus Culture and Next Generation Sequencing [ Time Frame: 1 day ]Diagnostic performance of molecular and culture techniques for S. aureus screening using nasal and groin swabs to determine whether the S. aureus retrieved on the skin and nares of patients who develop a joint infection is identical to the bacteria found in the wound of the PJI
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04666532
|United States, Pennsylvania|
|Rothman Orthopaedic Institute|
|Philadelphia, Pennsylvania, United States, 19107|