Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso
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|ClinicalTrials.gov Identifier: NCT04157894|
Recruitment Status : Recruiting
First Posted : November 8, 2019
Last Update Posted : November 8, 2019
The use of insecticide-treated bed nets (ITN) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance commonly used insecticides in mosquito populations. Newly developed, next-generation ITNs using two insecticides or an insecticide synergist and an insecticide are effective against resistant mosquitoes, but large-scale uptake of these nets has been slow due to higher costs and lack of enough evidence to support broad policy recommendations.
This observational study will occur alongside a pilot distribution of next-generation ITNs and collect data over three years on their entomological and epidemiological impact as well as anthropological factors that influence their uptake and use. Data collection will occur in three districts: one receiving dual-active ingredient ITNs, Interceptor® G2 (BASF), one receiving a standard pyrethroid long-lasting insecticidal net (LLIN), Interceptor® (BASF), and one receiving PermaNet®3.0 (Vestergaard) an LLIN containing an insecticide and an insecticide synergist. Data will be collected on malaria vector bionomics, disease epidemiology, and human behaviors in order to help better demonstrate the public health value of next-generation ITNs and to support donors, policymakers, and National Malaria Control Programs in their ITN decision-making and planning processes.
|Condition or disease||Intervention/treatment|
|Malaria||Other: Standard long-lasting insecticidal net Other: Chlorfenapyr insecticide treated net Other: Piperonyl butoxide long-lasting insecticidal net|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||6734 participants|
|Official Title:||Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso|
|Actual Study Start Date :||July 7, 2019|
|Estimated Primary Completion Date :||September 1, 2022|
|Estimated Study Completion Date :||December 31, 2022|
This group receives Interceptor ITNs during the mass distribution campaign.
Other: Standard long-lasting insecticidal net
Interceptor® (BASF) contains a pyrethroid insecticide
Other Name: Interceptor®
This group receives Interceptor G2 ITNs during the mass distribution campaign.
Other: Chlorfenapyr insecticide treated net
Interceptor® G2 (BASF) is an ITN containing two active ingredients: Alpha-cypermethrin, a pyrethroid insecticide, and chlorfenapyr, a pyrrole insecticide.
Other Name: Interceptor G2®
Piperonyl butoxide LLIN
This group receives PBO ITNs during the mass distribution campaign.
Other: Piperonyl butoxide long-lasting insecticidal net
PermaNet®3.0 (Vestergaard) contains deltamethrin, a pyrethroid insecticide, and piperonyl butoxide, an insecticide synergist.
Other Name: PermaNet®3.0
- Cumulative malaria incidence [ Time Frame: July 2019 to December 2022, monthly ]Malaria incidence measured through passive case detection at health facilities in each district. This measure accounts for symptomatic cases self-reporting to the formal health system for care.
- Vector species composition [ Time Frame: July 2019 to December 2022, monthly ]All Anopheles mosquitoes sampled during Centers for Disease Control and Prevention light traps (CDCLT) and human landing collections (HLC) will be identified morphologically to species group
- Species-specific population densities [ Time Frame: July 2019 to December 2022, monthly ]Based on Anopheles mosquitoes sampled during CDCLT
- Species-specific population densities [ Time Frame: July 2019 to December 2022, monthly ]Based on Anopheles mosquitoes sampled during HLC
- Biting behaviors [ Time Frame: July 2019 to December 2022, monthly ]Based on Anopheles mosquitoes sampled during CDCLT
- Biting behaviors [ Time Frame: July 2019 to December 2022, monthly ]Based on Anopheles mosquitoes sampled during HLC
- Estimated entomological inoculation rates [ Time Frame: July 2019 to December 2022, monthly ]Based on Anopheles mosquitoes sampled during CDCLT and HLC
- Insecticide resistance profile [ Time Frame: July 2019 to December 2022, monthly ]Measurement of kdr and ace-1 mutation frequencies, WHO tube bioassays at minimum and CDC bottle bioassays to characterize insecticide resistance intensity
- Parasite prevalence in children 6-59 months [ Time Frame: July 2019, July 2020, July 2021, July 2022 ]Prevalence calculated from cross-sectional surveys conducted during the peak transmission season.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04157894
|Contact: Molly Robertson, MPHemail@example.com|
|Contact: Joseph Wagman, PhDfirstname.lastname@example.org|
|Centre National de Recherche et de Formation sur le Paludisme||Recruiting|
|Ouagadougou, Burkina Faso, 01 BP 2208|
|Contact: Sagnon NFalé, MD email@example.com|
|Principal Investigator:||Molly Robertson, MPH||PATH|
|Principal Investigator:||Sagnon NFalé, MD||National Center for Research and Training on Malaria|