Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients
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|ClinicalTrials.gov Identifier: NCT04130347|
Recruitment Status : Completed
First Posted : October 17, 2019
Last Update Posted : October 18, 2019
|Condition or disease|
|Acute Kidney Injury|
Ethical approval was submitted and approved by the regional ethical committee, Etisk prövningsnämnd Uppsala, # 2017/418.
Patients were selected from the time span of april 2016 to september 2017. The investigators identified 499 patients that had undergone any of the selected procedures. The procedures were, pancreatic resection, HIPEC surgery in colorectal setting, gynecological debulking in metastasized ovarian cancer, and liver resection.
The risk of acute kidney injury (AKI) by the KDIGO definition during the postoperative period will be estimated in the group as a whole, and for each type of surgery separately. In addition the data will be stratified by sex to investigate systematic gender disparities or physiological differences. Length of stay, thirty day and sixty day mortality will secondary endpoints.
|Study Type :||Observational|
|Actual Enrollment :||499 participants|
|Official Title:||Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients|
|Actual Study Start Date :||April 1, 2016|
|Actual Primary Completion Date :||September 30, 2017|
|Actual Study Completion Date :||September 30, 2017|
|Gynecological debulking surgery|
- Incidence of AKI [ Time Frame: the first 24- 72 hours postop ]Frequency of AKI as defined by KDIGO
- Mortality [ Time Frame: 30, 60 and 360 days postoperatively ]30, 60, and 360 day mortality rate
- Major Adverse Kidney Events [ Time Frame: 30, 60 and 360 days postoperatively ]Renal composite outcome according to Major Adverse Kidney Events (MAKE)
- Fluid balance [ Time Frame: 24-72h ]Fluid balance during surgery, and the first postoperative days.
- Electrolyte disturbances [ Time Frame: 24-72h ]Any electrolyte disturbance.
Biospecimen Retention: None Retained