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Study to Evaluate the Effect of Rifampin and Rifabutin With Fedratinib in Healthy Adult Subjects

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ClinicalTrials.gov Identifier: NCT03983239
Recruitment Status : Not yet recruiting
First Posted : June 12, 2019
Last Update Posted : June 12, 2019
Sponsor:
Collaborator:
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation
Information provided by (Responsible Party):
Celgene

Brief Summary:

This is a 2-part study to evaluate the effect of multiple doses of rifampin or rifabutin on the PK, safety, and tolerability of single doses of fedratinib in healthy subjects. Each study part will consist of a nonrandomized, fixed-sequence, open-label design. The study parts can be run in any order or in parallel. Subjects may participate in one part only. For each part, subjects will participate as follows:

  • Screening
  • Treatment period (includes baseline)
  • Follow-up telephone call (4 days [± 2 days] after discharge) During the study, blood samples will be collected at prespecified times for PK. Subject safety will be monitored throughout the study.

Condition or disease Intervention/treatment Phase
Healthy Volunteers Drug: Fedratinib Drug: Rifampin Drug: Rifabutin Phase 1

Expanded Access : An investigational treatment associated with this study is available outside the clinical trial.   More info ...

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 32 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase 1, Open-label, 2-part Study to Evaluate the Effect of Rifampin and Rifabutin on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects
Estimated Study Start Date : December 15, 2019
Estimated Primary Completion Date : December 15, 2020
Estimated Study Completion Date : December 15, 2020

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Fedratinib plus Rifampin
A single dose of fedratinib on Day 1. On Days 9 through 18, once-daily (QD) doses of rifampin. On Day 17, a single dose of fedratinib will be concomitantly administered with rifampin.
Drug: Fedratinib
Fedratinib

Drug: Rifampin
Rifampin

Experimental: Fedratinib plus Rifabutin
A single dose of fedratinib on Day 1. On Days 9 through 18, once-daily (QD) doses of rifabutin. On Day 17, a single dose of fedratinib will be concomitantly administered with rifabutin.
Drug: Fedratinib
Fedratinib

Drug: Rifabutin
Rifabutin




Primary Outcome Measures :
  1. Fedratinib Pharmacokinetic - Cmax [ Time Frame: Up to approximately 8 days. ]
    Maximum observed plasma concentration

  2. Fedratinib Pharmacokinetic - Tmax [ Time Frame: Up to approximately 8 days. ]
    Time to maximum observed plasma concentration

  3. Fedratinib Pharmacokinetic - AUC0-t [ Time Frame: Up to approximately 8 days. ]
    Area under the curve from time zero to the last quantifiable concentration

  4. Fedratinib Pharmacokinetic - AUC0-∞ [ Time Frame: Up to approximately 8 days. ]
    Area under the curve from time zero extrapolated to infinity

  5. Fedratinib Pharmacokinetic - t1/2 [ Time Frame: Up to approximately 8 days. ]
    Terminal elimination half-life

  6. Fedratinib Pharmacokinetic - CL/F [ Time Frame: Up to approximately 8 days. ]
    Apparent total plasma clearance when dosed orally

  7. Fedratinib Pharmacokinetic - Vz/F [ Time Frame: Up to approximately 8 days. ]
    Apparent total volume of distribution when dosed orally


Secondary Outcome Measures :
  1. Adverse Events (AEs) [ Time Frame: From enrollment until at least 30 days after completion of study treatment ]
    Number of participants with adverse event



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Subjects must satisfy the following criteria to be enrolled in the study:

  1. Subject must understand and voluntarily sign an informed consent form (ICF) prior to any study-related assessments/procedures being conducted.
  2. Subject must be willing and able to communicate with the investigator and to adhere to the study visit schedule and other protocol requirements.
  3. Subject must be a male or female of any race from ≥ 18 and ≤ 65 years of age at the time of signing the informed Consent Form (ICF).
  4. Female subjects NOT of childbearing potential must:

    a. Have been surgically sterilized (hysterectomy or bilateral oophorectomy; proper documentation required) at least 6 months before Screening, or postmenopausal (defined as 24 consecutive months without menses before Screening, with a follicle-stimulating hormone [FSH] level in the post-menopausal range according to the laboratory used at Screening).

  5. Females of childbearing potential (FCBP) must:

    1. Have a negative pregnancy test as verified by the investigator at Screening and Baseline (prior to starting study treatment). She must agree to ongoing pregnancy testing during the course of the study, as applicable, and after end of study treatment. This applies even if the subject practices true abstinence from heterosexual contact.
    2. Either commit to true abstinence from heterosexual contact (which must be reviewed on a monthly basis, as applicable, and source documented) or agree to use, and be able to comply with, any one of the following highly effective contraception methods without interruption, beginning at least 14 days prior to starting investigational product (IP), during the study treatment, and for at least 30 days after the last dose of IP:

      • Intrauterine device (IUD; non-hormonal only); tubal ligation; or a partner with a vasectomy. The chosen form of birth control must be effective by the time the subject receives the first dose of IP.
  6. Male subjects must:

    a. Practice true abstinence from heterosexual contact (which must be reviewed on a monthly basis, as applicable, and source documented) or agree to use a barrier method of birth control (condoms not made from natural [animal] membrane [latex condoms are recommended]) during sexual contact with a pregnant female or FCBP while receiving study treatment, during any dose interruptions, and for at least 30 days after the last dose of IP, even if he has undergone a successful vasectomy.

  7. Must have a body mass index (BMI) ≥ 18 and ≤ 33 kg/m2 at screening.
  8. Must be healthy, as determined by the investigator on the basis of medical history, physical examination (PE), clinical laboratory test results, vital signs, and 12-lead ECG at screening and check-in (Day -1), as applicable:

    Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin must be within normal range on or before check-in (Day -1). Other clinical laboratory results must be either within normal range or deemed not clinically significant by the investigator. Any out of range lab tests may be repeated up to one time during the screening period and up to one time at check-in per Investigator discretion to confirm eligibility.

  9. Must be afebrile (febrile is defined as ≥ 38°C or 100.3°F).
  10. Supine systolic blood pressure (BP) must be in the range of 90 to 140 mmHg (inclusive), supine diastolic BP must be in the range of 50 to 90 mmHg (inclusive), and pulse rate must be in the range of 40 to 100 bpm (inclusive) at screening. Repeat vital signs may be measured at investigator discretion.
  11. Subject has a normal or clinically acceptable 12-lead ECG at screening; male subjects must have a corrected QT interval using Fridericia's formula (QTcF) value ≤ 430 msec and females must have a QTcF value ≤ 450 msec. An ECG may be repeated up to two times, and the average of the QTcF values will be used to determine subject eligibility.

Exclusion Criteria:

The presence of any of the following will exclude a subject from enrollment:

  1. History (ie, within 3 years) of any clinically significant neurological, GI, hepatic, renal, respiratory, cardiovascular, metabolic, endocrine, hematological, dermatological, psychological, or other major disorders as determined by the investigator.
  2. Any condition, including the presence of laboratory abnormalities, that places the subject at unacceptable risk if he or she were to participate in the study or confounds the ability to interpret data from the study (congenital nonhemolytic hyperbilirubinemia [eg, Gilbert's syndrome] is not acceptable).
  3. Subject has prior history of Wernicke's Encephalopathy (WE).
  4. Subject has signs or symptoms of WE (eg, severe ataxia, ocular paralysis, or cerebellar signs) without documented exclusion of WE by thiamine level and brain MRI.
  5. Subject has thiamine deficiency, defined as thiamine levels in whole blood below normal range according to institutional standard.
  6. Subject has active tuberculosis or another disease caused by mycobacteria.
  7. Use of any prescribed systemic or topical medication, including vaccines, within 30 days of the first dose administration (with the exception of any odansetron administered for purposes of this study).
  8. Use of any nonprescribed systemic or topical medication (including vitamin/mineral supplements and herbal medicines) within 14 days of the first dose administration (with the exception of acetaminophen up to 2 grams/day for no more than 3 consecutive days to treat minor illness or headache [per Investigator judgment]).
  9. Use of any metabolic enzyme inhibitors or inducers that would affect the relevant drugs within 30 days of the first dose administration unless determined by the investigator that there will be no impact on the study integrity or subject safety. The Indiana University "P450 Drug Interaction Table" should be used to determine inhibitors and/or inducers of metabolic enzymes. The sponsor should be contacted for questions about potential drug-drug interactions and exclusions/prohibitions when necessary.
  10. Exposure to an investigational drug (new chemical entity) within 30 days preceding the first dose administration or 5 half-lives of that investigational drug, if known (whichever is longer).
  11. Presence of any surgical or medical conditions possibly affecting drug absorption, distribution, metabolism, and excretion (eg, bariatric procedure). Appendectomy and cholecystectomy are acceptable.
  12. Donated blood or plasma within 8 weeks before the first dose administration.
  13. History of drug abuse (as defined by the current version of the Diagnostic and Statistical Manual [DSM]) within 2 years before dosing or positive drug screening test reflecting consumption of illicit drugs.
  14. History of alcohol abuse (as defined by the current version of the DSM) within 2 years before dosing or positive alcohol screen.
  15. Known to have serum hepatitis; known to be a carrier of the hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), or hepatitis C antibody (HCV Ab); have a positive result to the test for hepatitis B or hepatitis C virus at screening or have a positive result to the test for human immunodeficiency virus (HIV) antibodies at screening. Subjects whose results are compatible with prior immunization against hepatitis B may be included at the discretion of the investigator.
  16. Use of tobacco- or nicotine-containing products within 3 months prior to check-in.
  17. Subject has received live vaccination (excluding seasonal flu vaccination) within 90 days of first dosing.
  18. History of multiple drug allergies (ie, two or more).
  19. Allergic to or hypersensitive to any of the drugs used in the part of the study in which the subject will participate.
  20. Has any medical condition, medical history, or use of concomitant medication that is contraindicated in the applicable drug labeling.
  21. Female subject who is pregnant or breastfeeding.
  22. Subject is part of the clinical staff personnel or a family member of the clinical site staff.
  23. Subject has a hypersensitivity to ondansetron.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03983239


Contacts
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Contact: Associate Director Clinical Trial Disclosure 1-888-260-1599 clinicaltrialdisclosure@celgene.com

Sponsors and Collaborators
Celgene
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation
Investigators
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Study Director: Leon Carayannopoulos, MD Celgene

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Responsible Party: Celgene
ClinicalTrials.gov Identifier: NCT03983239     History of Changes
Other Study ID Numbers: FEDR-CP-002
U1111-1233-7946 ( Other Identifier: WHO )
First Posted: June 12, 2019    Key Record Dates
Last Update Posted: June 12, 2019
Last Verified: June 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description:

Information relating to our policy on data sharing and the process for requesting data can be found at the following link:

https://www.celgene.com/research-development/clinical-trials/clinical-trials-data-sharing/

Supporting Materials: Study Protocol
Statistical Analysis Plan (SAP)
Informed Consent Form (ICF)
Clinical Study Report (CSR)
Analytic Code
Time Frame: See Plan Description
Access Criteria: See Plan Description
URL: https://www.celgene.com/research-development/clinical-trials/clinical-trials-data-sharing/

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Celgene:
Healthy Subject
Fedratinib
Rifampin
Rifabutin
Drug Interaction

Additional relevant MeSH terms:
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Rifampin
Rifabutin
Antibiotics, Antitubercular
Antitubercular Agents
Anti-Bacterial Agents
Anti-Infective Agents
Leprostatic Agents
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 Enzyme Inducers
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C19 Inducers
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP3A Inducers