Propofol and Dexmedetomidine on Inflammation
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|ClinicalTrials.gov Identifier: NCT03600727|
Recruitment Status : Not yet recruiting
First Posted : July 26, 2018
Last Update Posted : July 26, 2018
|Condition or disease||Intervention/treatment||Phase|
|Inflammation Postoperative Delirium Anesthesia||Drug: Propofol Drug: Dexmedetomidine||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||200 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||Patients receiving total hip and knee arthroplasty will be intraoperative sedated by propofol or dexmedetomidine.|
|Masking:||Single (Outcomes Assessor)|
|Masking Description:||Outcomes Assessor will be blinded to this study.|
|Primary Purpose:||Supportive Care|
|Official Title:||Intraoperative Propofol and Dexmedetomidine on Peripheral Inflammation Induced by Hip or Knee Arthroplasty.|
|Estimated Study Start Date :||August 2018|
|Estimated Primary Completion Date :||September 2018|
|Estimated Study Completion Date :||December 2018|
Experimental: Propofol group
Patients in this arm will be sedated by propofol.
Propofol will be used to offer intraoperative sedation for patients in Propofol group.
Experimental: Dexmedetomidine group
Patients in this arm will be sedated by dexmedetomidine.
Dexmedetomidine will be used to offer intraoperative sedation for patients in Dexmedetomidine group.
- change of the concentration of IL-6 [ Time Frame: Preoperative and end of surgery ]Change of the concentration of plasma IL-6 from baseline to the end surgery
- Postoperative delirium [ Time Frame: Postoperative (1-3 days after surgery) ]The incidence of postoperative delirium
- Postoperative cognitive dysfunction [ Time Frame: Postoperative (7 and 30 days after surgery) ]The incidence of postoperative cognitive dysfunction
- change of the concentration of TNF-α [ Time Frame: Preoperative and end of surgery ]Change of the concentration of plasma TNF-α from baseline to the end surgery
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03600727
|Contact: Bin Mei, Ph.Demail@example.com|
|Contact: Xuesheng Liu, Ph.Dfirstname.lastname@example.org|
|Study Chair:||Zhaozhao Liang, Ph.D||The First Affiliated Hospital of Anhui Medical University|