Sex-specific Adaptation to Resistance Training in Older Adults
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|ClinicalTrials.gov Identifier: NCT03440099|
Recruitment Status : Suspended (COVID-19 pandemic makes it unsafe for older adults to participate in the study)
First Posted : February 20, 2018
Last Update Posted : April 19, 2021
|Condition or disease||Intervention/treatment||Phase|
|Biological Aging||Other: Resistance exercise training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Sex-specific Adaptation to Different Resistance Exercise Programs in Older Adults|
|Actual Study Start Date :||January 1, 2018|
|Estimated Primary Completion Date :||March 31, 2022|
|Estimated Study Completion Date :||March 31, 2022|
All participants will participate in the 16-week resistance exercise training program.
Other: Resistance exercise training
16-week exercise training program, wherein one leg undergoes traditional low-velocity, high-load resistance training and the other leg undergoes high-velocity, low-load power training.
- Change in peak isokinetic power [ Time Frame: This measure will be collected for each volunteer pre- and post-16 week exercise intervention and take approximately 30 minutes to collect for each time point. ]Peak isokinetic power at the whole muscle level will be evaluated using a dynamometer.
- Change in single fiber specific power [ Time Frame: This measure will be preformed on tissue biopsied from each volunteer pre- and post-16 week exercise intervention and requires approximately 1 week to collect per time point. ]Single fiber specific power will be measured from segments of chemically-skinned single human skeletal muscle fibers under maximal calcium-activated conditions, with muscle fiber type determined post-measurement by gel electrophoresis
- Change in myosin attachment time [ Time Frame: This measure will be preformed on tissue biopsied from each volunteer pre- and post-16 week exercise intervention and requires approximately one week to collect per time point. ]Myosin attachment time will be measured from segments of chemically-skinned single human skeletal muscle fibers under maximal calcium-activated conditions, with muscle fiber type determined post-measurement by gel electrophoresis.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03440099
|United States, Massachusetts|
|University of Massachusetts|
|Amherst, Massachusetts, United States, 01003|
|Principal Investigator:||Mark S Miller, PhD||University of Massachusetts, Amherst|