Genetic Influences Between Cognitive Function and BMI
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|ClinicalTrials.gov Identifier: NCT03116334|
Recruitment Status : Completed
First Posted : April 17, 2017
Last Update Posted : April 18, 2017
|Condition or disease|
Investigators will use existing data collected as part of the Texas Twin Project (TTP). TTP collected neuropsychological task data on cognition (executive functioning and general cognitive abilities) from a computerized test battery, as well as BMI data, on a sample of 869 twins. Investigators will use information from the known extent of genetic and environmental sharing between members of MZ (monozygotic; identical) and DZ (dizygotic; fraternal) twin pairs to quantify the genetic correlation between measures of cognition and BMI using biometric genetic modeling under the assumptions of the classical twin model. The specific aims are:
- To examine the association between BMI and executive functioning (EF) in a sample of 869 twin children, ages 7 to 15 years old, who participated in the Texas Twin Project (TTP)
- To gauge the specificity of EF-BMI relations relative to academic achievement and general cognitive abilities.
- To examine the relative contribution of genetic and environment influences to the inverse association between BMI and EF
|Study Type :||Observational|
|Actual Enrollment :||869 participants|
|Official Title:||Shared Genetic Influences Between Cognitive Function and Body Mass Index (BMI) in the Texas Twin Project|
|Actual Study Start Date :||September 2009|
|Actual Primary Completion Date :||December 2016|
|Actual Study Completion Date :||December 2016|
- Executive functioning [ Time Frame: 2 hours ]This measure will be derived from a computerized test battery incorporating the Animal Stroop, Stop Signal, Mickey (an anti- Trail Making, Local-Global, Plus-Minus, Digit Span Backward, Symmetry Span, Listening Recall, 2-Back, Keeping Track, and Running Memory for Letters tasks. A latent factor of variance common to all these tasks will be used to indicate "higher order executive functioning".
- Body mass index [ Time Frame: 10 minutes ]Heights and weights were measured by trained study personnel and BMI will be calculated as weight in kilograms (kg) divided by height in centimeters (cm) squared.
- General Cognitive Ability [ Time Frame: 1 hour ]This was assessed using the WASI-II
- Academic Achievement [ Time Frame: 30 minutes ]This was assessed using the Woodcock-Johnson-III Calculations and Passage Comprehension tests
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03116334
|United States, Texas|
|Children's Nutrition Research Center|
|Houston, Texas, United States, 77030|