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Genetic Influences Between Cognitive Function and BMI

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03116334
Recruitment Status : Completed
First Posted : April 17, 2017
Last Update Posted : April 18, 2017
Information provided by (Responsible Party):
Alexis Wood, Baylor College of Medicine

Brief Summary:
In this study the investigators will interrogate an existing data set to examine whether genetic variants contribute to an inverse association between weight status and cognitive function. Investigators hypothesize that body mass index (BMI) will be inversely related to a number of variables measuring cognitive function, and that that this inverse relation will be at least partially attributable to genetic variants which influence both BMI and cognition.

Condition or disease

Detailed Description:

Investigators will use existing data collected as part of the Texas Twin Project (TTP). TTP collected neuropsychological task data on cognition (executive functioning and general cognitive abilities) from a computerized test battery, as well as BMI data, on a sample of 869 twins. Investigators will use information from the known extent of genetic and environmental sharing between members of MZ (monozygotic; identical) and DZ (dizygotic; fraternal) twin pairs to quantify the genetic correlation between measures of cognition and BMI using biometric genetic modeling under the assumptions of the classical twin model. The specific aims are:

  • To examine the association between BMI and executive functioning (EF) in a sample of 869 twin children, ages 7 to 15 years old, who participated in the Texas Twin Project (TTP)
  • To gauge the specificity of EF-BMI relations relative to academic achievement and general cognitive abilities.
  • To examine the relative contribution of genetic and environment influences to the inverse association between BMI and EF

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Study Type : Observational
Actual Enrollment : 869 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Shared Genetic Influences Between Cognitive Function and Body Mass Index (BMI) in the Texas Twin Project
Actual Study Start Date : September 2009
Actual Primary Completion Date : December 2016
Actual Study Completion Date : December 2016

Primary Outcome Measures :
  1. Executive functioning [ Time Frame: 2 hours ]
    This measure will be derived from a computerized test battery incorporating the Animal Stroop, Stop Signal, Mickey (an anti- Trail Making, Local-Global, Plus-Minus, Digit Span Backward, Symmetry Span, Listening Recall, 2-Back, Keeping Track, and Running Memory for Letters tasks. A latent factor of variance common to all these tasks will be used to indicate "higher order executive functioning".

  2. Body mass index [ Time Frame: 10 minutes ]
    Heights and weights were measured by trained study personnel and BMI will be calculated as weight in kilograms (kg) divided by height in centimeters (cm) squared.

Secondary Outcome Measures :
  1. General Cognitive Ability [ Time Frame: 1 hour ]
    This was assessed using the WASI-II

  2. Academic Achievement [ Time Frame: 30 minutes ]
    This was assessed using the Woodcock-Johnson-III Calculations and Passage Comprehension tests

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   7 Years to 15 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Individuals from the Texas twin Project dataset, who were twins and higher-order multiples previously recruited from the Houston and Austin Metropolitan areas, via flyers, the internet (study website) and contact through public school rosters

Inclusion Criteria:

All participants in the TTP database with executive functioning and BMI data, without a parent-reported medical disorder affecting growth

Exclusion Criteria:

Parent-reported medical disorder affecting growth More than one sibling in the dataset (if triplets are present, only two randomly selecting siblings will be included).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03116334

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United States, Texas
Children's Nutrition Research Center
Houston, Texas, United States, 77030
Sponsors and Collaborators
Baylor College of Medicine
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Responsible Party: Alexis Wood, Assistant Professor, Baylor College of Medicine Identifier: NCT03116334    
Other Study ID Numbers: H-37801
First Posted: April 17, 2017    Key Record Dates
Last Update Posted: April 18, 2017
Last Verified: April 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: This protocol involves secondary data analysis of existing studies. Data will not be shared with other investigators since they should obtain data from the primary sources.

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Alexis Wood, Baylor College of Medicine:
executive functioning
general cognitive ability
twin study
Additional relevant MeSH terms:
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Nutrition Disorders
Body Weight