Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
|Official Title:||Basic Research on Carbon Monoxide's Headache Inducing Characteristics in a Humane Experimental Headache Model|
- Headache scores, 12 hours [ Time Frame: 12 hours ]Comparison between carbon monoxide and placebo (atmospheric air)
- Facial blood flow [ Time Frame: [ Time Frame: 0-180 min ] ]Carbon monoxide induced changes in facial blood flow before and after inhalation.
|Actual Study Start Date:||October 2016|
|Estimated Study Completion Date:||March 1, 2018|
|Estimated Primary Completion Date:||December 31, 2017 (Final data collection date for primary outcome measure)|
Active Comparator: Active carbon monoxide
Inhalation of carbon monoxide up to a carboxyhemoglobin concentration 22%
Other: Carbon monoxide
carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass
|Placebo Comparator: Air||
Room air will be administered as placebo
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
Please refer to this study by its ClinicalTrials.gov identifier: NCT03075020
|Contact: Hashmat Ghanizada, MDfirstname.lastname@example.org|
|Danish Headache Center||Recruiting|
|Glostrup, Denmark, 2600|
|Contact: Hashmat Ghanizada, MD 38633470 email@example.com|