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Investigating Accelerated Learning in Healthy Subjects

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03055884
Recruitment Status : Suspended (low numbers of participants)
First Posted : February 16, 2017
Last Update Posted : November 4, 2020
Sponsor:
Information provided by (Responsible Party):
Sven Vanneste, The University of Texas at Dallas

Brief Summary:
The purpose of this study is to investigate whether it is possible to accelerate learning and improve associative memory performance in healthy subjects, by (1) applying transcranial Direct Current Stimulation (tDCS) during a verbal paired-associate learning task and by (2) optimizing the learning method with repeated retrieval practice.

Condition or disease Intervention/treatment Phase
Healthy Adults Device: tDCS Behavioral: Verbal paired-associate learning task Not Applicable

Detailed Description:

Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.

Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical stimulation technique that has demonstrated to accelerate learning and improve memory in some studies. Previous research has also emphasized the importance of repeated retrieval practice as a way to accelerate learning and enhance associative memory performance. Therefore, this study will examine the effect of repeated retrieval practice on associative memory performance by using two versions of an associative memory task.

To investigate whether it is possible to accelerate learning and improve associative memory using tDCS and repeated retrieval practice, the performance in a Verbal Paired-Associate memory task during the first visit and 1 week after will be compared for four study groups. The first group will get active tDCS during a version of the verbal paired-associate learning task with repeated retrieval practice. The second group will get active tDCS during a version of the verbal paired-associate learning task without repeated retrieval practice. The third group will get sham tDCS during a version of the verbal paired-associate learning task with repeated retrieval practice and the fourth group will get Sham tDCS during a version of the verbal paired-associate learning task without repeated retrieval practice.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Investigating Accelerated Learning in Healthy Subjects
Actual Study Start Date : February 13, 2017
Actual Primary Completion Date : April 22, 2020
Estimated Study Completion Date : December 22, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory

Arm Intervention/treatment
Experimental: active tDCS with repeated retrieval practice
active tDCS with verbal paired-associate learning task with repeated retrieval practice
Device: tDCS
active tDCS versus sham tDCS

Behavioral: Verbal paired-associate learning task
with or without repeated retrieval practice

Experimental: active tDCS without repeated retrieval practice
active tDCS with verbal paired-associate learning task without repeated retrieval practice
Device: tDCS
active tDCS versus sham tDCS

Behavioral: Verbal paired-associate learning task
with or without repeated retrieval practice

Sham Comparator: Sham tDCS with repeated retrieval practice
sham tDCS with verbal paired-associate learning task with repeated retrieval practice
Behavioral: Verbal paired-associate learning task
with or without repeated retrieval practice

Sham Comparator: Sham tDCS without repeated retrieval practice
shamtDCS with verbal paired-associate learning task without repeated retrieval practice
Behavioral: Verbal paired-associate learning task
with or without repeated retrieval practice




Primary Outcome Measures :
  1. Associative Memory assessed by a Verbal Paired-Associate memory test [ Time Frame: baseline and 1 week after the tDCS ]
    Changes in performance in the Verbal Paired-Associate memory task is compared between the 4 groups (1. tDCS+verbal paired-associate learning task with repeated retrieval practice, 2. tDCS + verbal paired-associate learning task without repeated retrieval practice, 3. Sham tDCS+verbal paired-associate learning task with repeated retrieval practice, 4. Sham tDCS + verbal paired-associate learning task without repeated retrieval practice) to investigate the influence of tDCS and learning method on Associative Memory



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age: 18-35 years
  • Native English Speaker

Exclusion Criteria:

  • History of severe head injuries,epileptic insults, or heart disease
  • Severe psychiatric disorders and severe untreated medical problems.
  • Acquainted with the foreign language used in the learning task
  • Contraindications for tDCS (pregnant women, implanted devices)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03055884


Locations
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United States, Texas
The University of Texas of Dallas
Richardson, Texas, United States, 75080
Sponsors and Collaborators
The University of Texas at Dallas
Investigators
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Principal Investigator: Sven Vanneste The University of Texas at Dallas
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Responsible Party: Sven Vanneste, Associate professor, The University of Texas at Dallas
ClinicalTrials.gov Identifier: NCT03055884    
Other Study ID Numbers: 17-34
First Posted: February 16, 2017    Key Record Dates
Last Update Posted: November 4, 2020
Last Verified: November 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: Yes
Keywords provided by Sven Vanneste, The University of Texas at Dallas:
transcranial Direct Current Stimulation (tDCS)
accelerated learning
memory