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Step-reduction in Older Men and Women (CDA-SR)

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ClinicalTrials.gov Identifier: NCT03039556
Recruitment Status : Completed
First Posted : February 1, 2017
Last Update Posted : February 1, 2017
Sponsor:
Collaborator:
Canadian Diabetes Association
Information provided by (Responsible Party):
Stuart Phillips, McMaster University

Brief Summary:
This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.

Condition or disease Intervention/treatment Phase
Older Adults Reduced Physical Activity Behavioral: Normal Daily Steps Behavioral: Step-Reduction Behavioral: Return to Normal Daily Steps Not Applicable

Detailed Description:
Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness. Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults. However, the recovery capacity of older adults after such physical inactivity remains unknown. This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Influence of Acute Physical Inactivity on Metabolic Function in Older Men and Women
Study Start Date : September 2015
Actual Primary Completion Date : May 2016
Actual Study Completion Date : May 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Health Checkup

Arm Intervention/treatment
Experimental: Change in physical activity for older adults
Older adult participants undergo alterations in daily ambulation by completing Normal Daily Steps for one week, followed by a two-week Step-Reduction and a subsequent Return to Normal Daily Steps for two weeks
Behavioral: Normal Daily Steps
Complete normal daily ambulation for one week

Behavioral: Step-Reduction
Reduce daily ambulation to fewer than 1000 steps per day for two weeks

Behavioral: Return to Normal Daily Steps
Increase daily ambulation to 100% of normal daily step-count for two weeks




Primary Outcome Measures :
  1. Change in Insulin Sensitivity [ Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5) ]
    Assessed via Matsuda ISI


Secondary Outcome Measures :
  1. Change in lean tissue mass [ Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5) ]
    Assessed via Dual Energy X-Ray Absorptiometry

  2. Change in Peak Isometric Maximal Voluntary Leg Extension Strength [ Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5) ]
    Assessed via muscle dynamometry

  3. Change in Muscle Protein Synthesis [ Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5) ]
    Obtained via vastus lateralis muscle biopsy



Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 80 Years   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Non-smoker

Exclusion Criteria:

  • Use of assistive walking devices
  • Chronic use of analgesic or anti-inflammatory drugs
  • History of neuromuscular problems or muscle and/or bone wasting disease
  • Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
  • Daily use of statins, particularly simvastatin and atorvastatin
  • Use of medications known to affect protein metabolism
  • Normally complete fewer than 3000 steps per day

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03039556


Locations
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Canada, Ontario
Exercise Metabolism Research Laboratory, McMaster Univeristy
Hamilton, Ontario, Canada, L8S 4K1
Sponsors and Collaborators
McMaster University
Canadian Diabetes Association
Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Stuart Phillips, Professor, McMaster University
ClinicalTrials.gov Identifier: NCT03039556    
Other Study ID Numbers: 0574
First Posted: February 1, 2017    Key Record Dates
Last Update Posted: February 1, 2017
Last Verified: January 2017