Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003 (PharmacogWP3)
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|ClinicalTrials.gov Identifier: NCT02899403|
Recruitment Status : Unknown
Verified June 2019 by University Hospital, Lille.
Recruitment status was: Recruiting
First Posted : September 14, 2016
Last Update Posted : June 26, 2019
In the perspective to better evaluate the efficacy of new treatment strategies for Alzheimer disease (AD), it appears important to develop experimental paradigms to precisely measure cognitive endpoints/biomarkers that may be used in healthy volunteers as tools to validate drug efficacy profile.
The use of Electroencephalography (EEG) may be, therefore, a good candidate. The purpose of the present study is to use EEG to more precisely explore cognitive processes in healthy subjects, with a particular interest in episodic and working memory functions that are usually altered in both AD and Mild Cognitive Impairment (MCI) as well as to better understand underlying neural mechanisms involved in these processes.
|Condition or disease||Intervention/treatment||Phase|
|Alzheimer Disease ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)||Other: Rapid Visual Information Processing (RVIP) test||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -A Pilot Study WP3 P003|
|Actual Study Start Date :||May 19, 2017|
|Estimated Primary Completion Date :||December 2020|
|Estimated Study Completion Date :||December 2020|
|Experimental: healthy subjects||
Other: Rapid Visual Information Processing (RVIP) test
Rapid Visual Information Processing is a measure of sustained attention.
- EEG spectral power during RVIP task as compared to resting state [ Time Frame: within 7 days after inclusion ( session1) ]The Rapid Visual Information Processing (RVIP®) is a test of sustained attention and has proved useful in many studies in which drugs are used to help develop a disease model. It is sensitive to dysfunction in the parietal and frontal lobe areas of the brain
- EEG spectral power during PRM task as compared to resting state [ Time Frame: within 7 days after inclusion ( session1) ]the Pattern Recognition Memory (PRM®) is a test assessing visual recognition memory, considered as a sensitive measure of medial temporal areas dysfunction. It is a useful tool for assessing patients with MCI and AD
- RVIP latency of responses [ Time Frame: within 7 days after inclusion ( session1) and within 7days after session 1 (=session2) ]
- PRM number of errors [ Time Frame: within 7 days after inclusion ( session1) and within 7 days after session 1 (=session2) ]
- PRM latency of responses [ Time Frame: within 7 days after inclusion (=session1) and within 7 days after session 1 (=session2) ]
- difference between session 2 and session 1 EEG Spectral power during RVIP task [ Time Frame: at 7 days after session 1 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02899403
|Contact: Régis Bordet, MD,PhD||188.8.131.52.49 ext +firstname.lastname@example.org|
|Hôpital Cardiologique, CIC||Recruiting|
|Principal Investigator: Dominique Deplanque, MD,PhD|
|Principal Investigator:||Dominique Deplanque, MD, PhD||University Hospital, Lille|