Optimizing Diagnosis Of Primary Aldosteronism (ODPA)
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To optimize the confirmatory tests for primary aldosteronism.
Condition or disease
In this study, the investigators aim to optimize the three confirmatory tests: salt loading, captopril challenge and fludrocortisone suppression, and to confirm a better choice of confirming testing for single or combined diagnosis of primary aldosteronism. Additionally, the investigators plan to collect blood and tissue samples of PA patients for genetic testing, and to proceed a long-term follow-up for further investigating the mechanism underlying PA and evaluating the cardio-cerebrovascular complications risk.
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Layout table for eligibility information
Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Group 1: Who was diagnosed with hypertension according to JNC standard and was considered with the possibility of primary aldosteronism.
Group 2: Control Groups, one group for those without hypertension or with primary hypertension; the other group for those with adrenal diseases except for primary aldosteronism.
With adrenal diseases
Pregnant or during lactation period;
Under 18 yr;
BMI ≤ 19 or ≥ 35
With Cancer medical history
Been through cardiovascular diseases in the past 3 months;
Been through malignant arrhythmia, respiratory muscle paralysis or skeletal muscle paralysis caused by hypokalemia.