Healthy Aging Longitudinal Study in Taiwan (HALST)
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|ClinicalTrials.gov Identifier: NCT02677831|
Recruitment Status : Active, not recruiting
First Posted : February 9, 2016
Last Update Posted : March 31, 2017
National Health Research Institutes, Taiwan
Shin Kong Wu Ho-Su Memorial Hospital
Hope Doctors Hospital
Changhua Christian Hospital
Yuan's General Hospital
Mennonite Christian Hospital
CHC Hospital Group
University of California, San Francisco
Information provided by (Responsible Party):
Chao A. Hsiung, National Health Research Institutes, Taiwan
The general aim of this study is to establish a longitudinal cohort of older persons in order to examine the physiological, environmental and genetic risk factors for physical disability, frailty, cardiovascular disease, and neuropsychiatric disorders in older persons and to examine the benefit of healthy lifestyles. The findings from this study will provide information necessary for the development of effective health policy for aging people.
|Condition or disease|
|Cardiovascular Diseases Metabolic Diseases|
Show detailed description
|Study Type :||Observational|
|Actual Enrollment :||5664 participants|
|Official Title:||Healthy Aging Longitudinal Study in Taiwan (HALST)|
|Study Start Date :||July 2008|
|Actual Primary Completion Date :||March 2013|
|Estimated Study Completion Date :||December 2020|
Primary Outcome Measures :
- Independence in daily life assessed by Barthel Index [ Time Frame: 20 years ]The Barthel Index will be adapted to assess the ability to cope with 10 items of daily activities. These tasks include feeding, moving from wheelchair to bed, personal toilet, getting on and off the toilet, bathing, walking on a level surface, ascending and descending stairs, dressing, controlling bowel, and controlling bladder. The total score ranges from 0 to 100, with 100 representing full independence in doing daily activities.
- Independence in daily life assessed by Lawton-Brody Instrumental Activities of Daily Living (IADL) scale [ Time Frame: 20 years ]IADL scale is used to measure a participant's ability to adapt to the environment and consists of 8 tasks: shopping, housekeeping, money management, food preparation, laundry, transportation, use of the telephone, and medications. The total score is from 0 (worst) to 8 (best).
- Declined rate of physical performance assessed by peak flow test [ Time Frame: 20 years ]The peak flow test, is a measure of lung function, the participant is asked to take a deep breath and blow as fast and hard as possible into the meter at a standing or sitting position. The maximum value in liter per minute of three to five trials of forced expiration is chosen as the peak flow.
- Declined rate of physical performance assessed by grip strength [ Time Frame: 20 years ]The participant is instructed to use the dominant hand to grip the dynamometer as hard as possible three times. The maximum value in kilograms of three trials is recorded as maximal grip strength.
- Declined rate of physical performance assessed by Summary Physical Performance Battery (SPPB) [ Time Frame: 20 years ]The SPPB, is a measure of lower extremity function and represents the participant's performance on three performance-based tests: 4-meter timed walk, five chair stands, and balance in three different standing positions side by side, semi-tandem, and full tandem. Participants will receive a score of 0 to 4 for each test. The summary performance score is the sum of scores calculated across the three tests, with 0 representing the worst and 12 the best.
- Cardiovascular disease incidence by linking the National Health Insurance Research Database in Taiwan [ Time Frame: 20 years ]
- Dementia incidence by linking the National Health Insurance Research Database in Taiwan [ Time Frame: 20 years ]
- Overall cancer incidence by linking the National Health Insurance Research Database in Taiwan [ Time Frame: 20 years ]
- All cause mortality [ Time Frame: 20 years ]
Biospecimen Retention: Samples With DNA
whole blood, serum, urine.
No Contacts or Locations Provided