The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02434783|
Recruitment Status : Completed
First Posted : May 5, 2015
Last Update Posted : August 5, 2016
Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow. Explanations have therefore in addition been linked to mitochondrial dysfunction of skeletal muscles.
This study will elucidate whether there is a relation between clinical variables of the different levels of arterial insufficiency in peripheral arterial disease and mitochondrial respiratory capacity.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||16 participants|
|Official Title:||The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity|
|Study Start Date :||May 2015|
|Actual Primary Completion Date :||April 2016|
|Actual Study Completion Date :||April 2016|
1st level of arterial insufficiency
asymptomatic PAD patients
2nd level of arterial insufficiency
Intermittent claudication patients
3rd level of arterial insufficiency
Critical limb ischemia patients
No arterial insufficiency
Healthy individuals (control)
- mitochondrial respiratory capacity [ Time Frame: 1 hour ]measured in oxygen glux in pmol.s-1.mg-1, using mitochondrial respirometry on an Oxygraph-2k (Oroboros Instruments, Austria).
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02434783
|Department of Circulation and Medical Imaging|
|Study Director:||Øyvind Rognmo||Norwegian University of Science and Technology|