Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study
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|ClinicalTrials.gov Identifier: NCT02357550|
Recruitment Status : Completed
First Posted : February 6, 2015
Last Update Posted : January 18, 2016
This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion.
- Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.
- Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.
- Altered oxygen consumption during hyperketonemia in healthy subjects.
|Condition or disease||Intervention/treatment||Phase|
|Ketone Body Metabolism Brain Metabolism||Drug: ketone Drug: placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||9 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study|
|Study Start Date :||March 2015|
|Actual Primary Completion Date :||January 2016|
|Actual Study Completion Date :||January 2016|
Placebo Comparator: Control
Saline infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy
Ketone infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy
3-OHB is infused intravenously.
- Glucose metabolism in brain, CMR [ Time Frame: t=240-360 minutes ]cerebral glucose metabolism measured by PET tracer during the above time frame
- Stress metabolism [ Time Frame: 0-360 minutes ]growth hormone, cortisol, glucagon, adrenalin, ghrelin.
- Oxygen use [ Time Frame: T=150-200 minutes ]cerebral oxygen consumption measured by PET tracer during the above time frame
- cerebral blood flow [ Time Frame: t=180-250 minutes ]cerebral blood flow measured by PET tracer during the above time frame
- Intramuscular signaling [ Time Frame: t= 260 minutes ]protein and insulin signaling in muscle
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02357550
|Aarhus University Hospital|
|Aarhus, Denmark, 8000|
|Principal Investigator:||Mads Svart, MD||Aarhus University / Aarhus University Hospital|