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Postoperative Atrial Fibrillation and Long-term Survival (POAF)

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ClinicalTrials.gov Identifier: NCT02349269
Recruitment Status : Completed
First Posted : January 28, 2015
Last Update Posted : January 28, 2015
Sponsor:
Collaborator:
University of Eastern Finland
Information provided by (Responsible Party):
Kuopio University Hospital

Brief Summary:
The aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (POAF) and late cardiovascular morbidity and mortality.

Condition or disease
Death Stroke Myocardial Infarction

Detailed Description:

The material of this retrospective study consist patients without preoperative history of atrial fibrillation, participated in three different randomized controlled trials previously . A total of 519 consecutive patients underwent coronary artery bypass surgery, aortic valve replacement or combined aortic valve with coronary bypass surgery in Kuopio University Hospital from 2004 to 2008. Patients with previous episodes of atrial fibrillation (AF) or flutter and also patients with mitral valve surgery were excluded. All patients had continuous postoperative ECG monitoring for at least 48 hours. AF episodes lasting longer than 5 minutes were registered. Thereafter 12 lead ECG was recorded daily and in case of symptoms of rhythm disturbances.

Medical records were reviewed during 2012 using standardized data collection protocol. Statistics Finland database was used for mortality data.


Study Type : Observational [Patient Registry]
Actual Enrollment : 519 participants
Target Follow-Up Duration: 105 Months
Official Title: Postoperative Atrial Fibrillation After Cardiac Surgery is Not an Independent Risk Factor for Long-term Cardiovascular Morbidity and Mortality in Anticoagulated Patients
Study Start Date : January 2012
Actual Primary Completion Date : December 2012
Actual Study Completion Date : September 2014

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. cardiovascular and all-cause death [ Time Frame: 1-105 month ]
  2. stroke [ Time Frame: 1-105 month ]
  3. late atrial fibrillation [ Time Frame: 1-105 month ]
  4. myocardial infarction [ Time Frame: 1-105 month ]


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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients without preoperative history of atrial fibrillation, participated in three different randomized controlled trials previously
Criteria

Inclusion Criteria:

  • previously cardiac operation, CABG or AVR

Exclusion Criteria:

  • Previous Atrial fibrillation

Responsible Party: Kuopio University Hospital
ClinicalTrials.gov Identifier: NCT02349269     History of Changes
Other Study ID Numbers: samuelm1
First Posted: January 28, 2015    Key Record Dates
Last Update Posted: January 28, 2015
Last Verified: November 2014

Keywords provided by Kuopio University Hospital:
Atrial fibrillation
CABG
Stroke

Additional relevant MeSH terms:
Atrial Fibrillation
Infarction
Myocardial Infarction
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Ischemia
Necrosis
Myocardial Ischemia
Vascular Diseases