Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02303067|
Recruitment Status : Completed
First Posted : November 27, 2014
Last Update Posted : December 6, 2018
- This study is designed for people who need a standard, non-research invasive coronary angiogram to find out if they have heart disease. Researchers want to take a computed tomography (CT) scan of people s hearts before their procedure to see if this less invasive test can also diagnose coronary artery disease.
- To learn if a new way to view CT pictures is able to accurately diagnose coronary artery disease.
- People age 55 and older who need a coronary angiogram.
- Participants will be screened with their medical records.
- Participants may give a blood sample.
- Participants may have a CT scan of the heart with and without contrast. The CT scan will not interfere with their medical care.
- Participants blood pressure and heart rhythm will be monitored before, during, and after the CT scan. They may have an electrocardiogram.
- Before the scan, participants will have an intravenous catheter put into their arm. It will be used to inject contrast.
- Participants may take a beta blocker to slow their heart rate.
- Participants may take nitroglycerin under their tongue. It will enlarge their heart blood vessels and improve picture quality. It may cause a flushing sensation or headache.
- Participants will lie on their back on a padded table. The table slides into a large, donut-shaped machine. An x-ray tube will move around their body, taking pictures. They will be asked to hold their breath for 5 seconds at a time.
- Participants will be called 30 days after their angiogram. They will answer questions about their health, hospital visits, or medical treatments.
|Condition or disease|
|Coronary Artery Disease|
Coronary calcium can impair the accurate evaluation of the coronary arteries with coronary computed tomography angiography (CCTA). A novel approach to potentially overcome this limitation is coronary calcium subtraction, where areas of calcification identified on a non-contrast scan are removed from the contrast enhanced images.
|Study Type :||Observational|
|Actual Enrollment :||13 participants|
|Official Title:||Prospective International Study of Coronary Subtraction Using 320 Row-Detector CT|
|Study Start Date :||January 6, 2015|
|Actual Primary Completion Date :||August 13, 2018|
|Actual Study Completion Date :||August 13, 2018|
- Coronary substraction CCTA improves the diagnostic accuracy. [ Time Frame: 3 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02303067
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Marcus Y Chen, M.D.||National Heart, Lung, and Blood Institute (NHLBI)|