Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)
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|ClinicalTrials.gov Identifier: NCT02303067|
Recruitment Status : Recruiting
First Posted : November 27, 2014
Last Update Posted : April 25, 2018
- This study is designed for people who need a standard, non-research invasive coronary angiogram to find out if they have heart disease. Researchers want to take a computed tomography (CT) scan of people s hearts before their procedure to see if this less invasive test can also diagnose coronary artery disease.
- To learn if a new way to view CT pictures is able to accurately diagnose coronary artery disease.
- People age 55 and older who need a coronary angiogram.
- Participants will be screened with their medical records.
- Participants may give a blood sample.
- Participants may have a CT scan of the heart with and without contrast. The CT scan will not interfere with their medical care.
- Participants blood pressure and heart rhythm will be monitored before, during, and after the CT scan. They may have an electrocardiogram.
- Before the scan, participants will have an intravenous catheter put into their arm. It will be used to inject contrast.
- Participants may take a beta blocker to slow their heart rate.
- Participants may take nitroglycerin under their tongue. It will enlarge their heart blood vessels and improve picture quality. It may cause a flushing sensation or headache.
- Participants will lie on their back on a padded table. The table slides into a large, donut-shaped machine. An x-ray tube will move around their body, taking pictures. They will be asked to hold their breath for 5 seconds at a time.
- Participants will be called 30 days after their angiogram. They will answer questions about their health, hospital visits, or medical treatments.
|Condition or disease|
|Coronary Artery Disease|
Coronary calcium can impair the accurate evaluation of the coronary arteries with coronary computed tomography angiography (CCTA). A novel approach to potentially overcome this limitation is coronary calcium subtraction, where areas of calcification identified on a non-contrast scan are removed from the contrast enhanced images.
|Study Type :||Observational|
|Estimated Enrollment :||125 participants|
|Official Title:||Prospective International Study of Coronary Subtraction Using 320 Row-Detector CT|
|Study Start Date :||January 6, 2015|
|Estimated Primary Completion Date :||April 1, 2019|
|Estimated Study Completion Date :||April 1, 2019|
- Coronary substraction CCTA improves the diagnostic accuracy. [ Time Frame: 3 months ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02303067
|Contact: Marsha Block, R.N.||(301) email@example.com|
|Contact: Marcus Y Chen, M.D.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Marcus Y Chen, M.D.||National Heart, Lung, and Blood Institute (NHLBI)|