The Suitability of Sniff Dog as a Tool in Screening Tumors
Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in screening cancer patients in health examination. Trained dogs will sniff serum from participants who are attending the annual health examination to identify potential or high risk subjects, and the results will be compared with the outcome of the traditional health examination, and the high risk subjects will be followed periodically for at least five years.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Suitability of Sniff Dog as a Tool in Screening Tumors-- a Prospective Observational Study|
- Sensitivity and specificity in screening cancer patients [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination or the currently used methods as non-cancer subjects or at the end of the study, 5 years later still without cancer.
- Behavior patterns of sniff dogs to different diseases [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]The behavior (lying before the tank for positive, neglecting the tanks) of the dog will be recorded and compared with the results of the pathological examination.
- The substances used by the sniff dogs to identifying tumors [ Time Frame: up to 5 years ] [ Designated as safety issue: No ]GCMS etc will be used to compare the volatile compounds between the sera from cancers patients and the from normal subjects, the suspected VOCs will be tested by the dog for conformation.
Biospecimen Retention: Samples Without DNA
|Study Start Date:||January 2014|
|Estimated Study Completion Date:||March 2019|
|Estimated Primary Completion Date:||March 2014 (Final data collection date for primary outcome measure)|
faculty staff and their adult family members
faculties and their adult family members of the Third Xiang-Ya Hospital
Please refer to this study by its ClinicalTrials.gov identifier: NCT02049645
|Contact: Chang-Qing Gao, MD PhD||86 firstname.lastname@example.org|
|Contact: Ya-Qin Wang, MD PhD||86 email@example.com|
|The Third Xiang-Ya Hospital||Recruiting|
|Changsha, Hunan, China, 410013|
|Contact: Chang-Qing Gao, MD PhD 86 139 7498 1039 firstname.lastname@example.org|
|Contact: Ya-Qin Wang, MD PhD 152 7481 0930 email@example.com|
|Principal Investigator:||Chang-Qing Gao, MD PhD||Central South University|