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Advanced Analysis of the Carotid Phonoangiography and Diseases

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ClinicalTrials.gov Identifier: NCT02049463
Recruitment Status : Unknown
Verified January 2014 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
First Posted : January 30, 2014
Last Update Posted : January 30, 2014
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:

Purpose: To investigate the different sound spectrum of carotid arteries and to analyze its relationship to the vessel disease, and to build a new biomarker about vascular disorder.

Methods: To record the carotid phonoangiography with digital stereoscopy and analysis the spectrum with different algorithm such as FFT, wavelet, entropy, complexity, and HHT. The results will be correlated and comparison to the finding in clinical, carotid Doppler and duplex, CTA, MR, and catheter angiography.

Statistics:

The significance of difference between parameters was computed using t-tests or paired t-test etc. A p value <0.05 is defined as significant.


Condition or disease
Carotid Atherosclerosis Seeing Sounds as Colors Stenosis Stroke

Detailed Description:

The investigators plan to recruit data from patients that come to their department for angiography study and intervention (n=300) with different disease entity such as atherosclerosis, tumor, aneurysm, arteriovenous malformation or fistula, and other vascular disorders. A period of about 20 seconds of the carotid phonoangiography was recorded.

Standard for comparison: catheter angiography, CTA, MRI/MRA. The degree of stenosis, the wall thickness, SI and density change was clustered and compared. The clinical and laboratory data will be reviewed and the vascular risk factors will be calculated.

Spectrum analysis: The sound spectrum will be analysis with the FFT, wavelet, entropy, complexity, and HHT algorithms.

The correlation between change of spectrums and also the correlated clinical, images, and laboratory change will be further analysis by statistic method.


Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Advanced Analysis of the Carotid Phonoangiography and Diseases
Study Start Date : February 2014
Estimated Primary Completion Date : February 2016
Estimated Study Completion Date : February 2016



Primary Outcome Measures :
  1. progression of stenosis [ Time Frame: three years ]
    Follow-up the severity of the carotid stenosis and correlate its wall change


Secondary Outcome Measures :
  1. wall change [ Time Frame: three years ]
    correlate the phonographic change with the follow up CTA wall change.



Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
the patients who is going to have carotid angiography study and with informed consent signed.
Criteria

Inclusion Criteria:

  1. Age: 20 years old to 99 years old
  2. Gender: Unlimited
  3. Because different types of brain diseases, those who received conventional catheter vascular examination.

Exclusion Criteria:

  1. Neck inflammation locally who can not admit the sound.
  2. Due to inability to cooperate to accept those recordings.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02049463


Contacts
Contact: Hon-man Liu, MD, MBA 886-2-23123456 ext 70329 hmliu@ntu.edu.tw

Locations
Taiwan
Hon-Man Liu Not yet recruiting
Taiwan, Taiwan, 10002
Contact: Hon-Man Liu, MD, MBA    886-2-23123456 ext 70329    hmliu@ntu.edu.tw   
Principal Investigator: Hon-Man Liu, MD, MBA         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Hon-man Liu, MD, MBA National Taiwan University Hospital

Responsible Party: National Taiwan University Hospital, Chairman
ClinicalTrials.gov Identifier: NCT02049463     History of Changes
Other Study ID Numbers: 201311042RIND
First Posted: January 30, 2014    Key Record Dates
Last Update Posted: January 30, 2014
Last Verified: January 2014

Keywords provided by National Taiwan University Hospital:
carotid artery
sound
stenosis
wall
stroke

Additional relevant MeSH terms:
Atherosclerosis
Carotid Artery Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases