Advanced Analysis of the Carotid Phonoangiography and Diseases
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|ClinicalTrials.gov Identifier: NCT02049463|
Recruitment Status : Unknown
Verified January 2014 by National Taiwan University Hospital.
Recruitment status was: Not yet recruiting
First Posted : January 30, 2014
Last Update Posted : January 30, 2014
Purpose: To investigate the different sound spectrum of carotid arteries and to analyze its relationship to the vessel disease, and to build a new biomarker about vascular disorder.
Methods: To record the carotid phonoangiography with digital stereoscopy and analysis the spectrum with different algorithm such as FFT, wavelet, entropy, complexity, and HHT. The results will be correlated and comparison to the finding in clinical, carotid Doppler and duplex, CTA, MR, and catheter angiography.
The significance of difference between parameters was computed using t-tests or paired t-test etc. A p value <0.05 is defined as significant.
|Condition or disease|
|Carotid Atherosclerosis Seeing Sounds as Colors Stenosis Stroke|
The investigators plan to recruit data from patients that come to their department for angiography study and intervention (n=300) with different disease entity such as atherosclerosis, tumor, aneurysm, arteriovenous malformation or fistula, and other vascular disorders. A period of about 20 seconds of the carotid phonoangiography was recorded.
Standard for comparison: catheter angiography, CTA, MRI/MRA. The degree of stenosis, the wall thickness, SI and density change was clustered and compared. The clinical and laboratory data will be reviewed and the vascular risk factors will be calculated.
Spectrum analysis: The sound spectrum will be analysis with the FFT, wavelet, entropy, complexity, and HHT algorithms.
The correlation between change of spectrums and also the correlated clinical, images, and laboratory change will be further analysis by statistic method.
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Advanced Analysis of the Carotid Phonoangiography and Diseases|
|Study Start Date :||February 2014|
|Estimated Primary Completion Date :||February 2016|
|Estimated Study Completion Date :||February 2016|
- progression of stenosis [ Time Frame: three years ]Follow-up the severity of the carotid stenosis and correlate its wall change
- wall change [ Time Frame: three years ]correlate the phonographic change with the follow up CTA wall change.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02049463
|Contact: Hon-man Liu, MD, MBA||886-2-23123456 ext firstname.lastname@example.org|
|Hon-Man Liu||Not yet recruiting|
|Taiwan, Taiwan, 10002|
|Contact: Hon-Man Liu, MD, MBA 886-2-23123456 ext 70329 email@example.com|
|Principal Investigator: Hon-Man Liu, MD, MBA|
|Principal Investigator:||Hon-man Liu, MD, MBA||National Taiwan University Hospital|