Effects of Obesity and Physical Inactivity on Pregnancy Outcomes
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|ClinicalTrials.gov Identifier: NCT02039414|
Recruitment Status : Completed
First Posted : January 17, 2014
Results First Posted : June 7, 2016
Last Update Posted : August 22, 2016
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||40 participants|
|Official Title:||Effects of Physical Activity on Maternal Lipid Metabolism, Oxidative Stress, and Neonatal Outcomes in Obese Pregnancy|
|Study Start Date :||October 2013|
|Actual Primary Completion Date :||March 2015|
|Actual Study Completion Date :||December 2015|
Pregnant women with a BMI≥30kg/m2 and sedentary lifestyle
Pregnant women with a BMI≥30kg/m2 and exercising >150min/week
- Neonatal Adiposity [ Time Frame: 24-48 hr after delivery ]Within 48 hours of delivery, neonatal body composition (% fat mass) will be measured by skin fold thickness measurement and by air displacement plethysmography (Pea Pod, Life Measurement, Inc., Concord, CA) in the CRU at WUSM.
- Neonatal Insulin Resistance [ Time Frame: Immediately after delivery ]Infant HOMA-IR will be determined by measuring umbilical cord plasma glucose and insulin concentrations at parturition vis cord blood collection. Cord blood will be collected within 30 min of delivery, centrifuged for 10 min at 3000rpm to remove plasma, and stored at -80.
- Maternal Inflammation [ Time Frame: This was taken while fasted and under resting conditions at the beginning of visit 2 (between 32 and 37 weeks gestation). This value was only measured at baseline (i.e. one timepoint). ]High-Sensitivity C-reactive protein was measured.
- Maternal Lipid Oxidation [ Time Frame: Visit 2 (32-37 weeks gestation)- reported lipid oxidation is the average of lipid oxidation over the course of the 30min exercise bout (i.e. data collected at minutes 8-10, minutes 18-20, and minutes 28-30 of exercise, all averaged together). ]The investigators will measure maternal lipid oxidation rate using indirect calorimetry (True One 2400, Parvo Medics, Sandy, UT) before, during, and after acute exercise. This will involve placing a hoodlike device over the subject's head as they lay supine (rest).During exercise, this involved using a mouthpiece and noseclips. Using both techniques, The investigators will be able to calculate lipid oxidation rates from the volumes of CO2 produced and volumes of O2 used.The reported measure is lipid oxidation rate during exercise. The equation used to calculate lipid oxidation is: lipid oxidation (g/min) = 1.695 VO2- 1.701 VCO2 .
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02039414
|United States, Missouri|
|Washington University in St. Louis|
|St. Louis, Missouri, United States, 63108|
|Principal Investigator:||William T Cade, PT, PhD||Washington University School of Medicine|