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The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02038595
Recruitment Status : Completed
First Posted : January 16, 2014
Last Update Posted : March 30, 2020
Sponsor:
Collaborator:
NYU Langone Health
Information provided by (Responsible Party):
Yale University

Brief Summary:
This study seeks to assess a novel imaging technique to image brown adipose tissue utilizing the norepinephrine transporter.

Condition or disease Intervention/treatment Phase
Brown Adipose Tissue Radiation: PET imaging Early Phase 1

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
Study Start Date : September 2012
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Healthy subjects
Healthy subjects (male, female)
Radiation: PET imaging



Primary Outcome Measures :
  1. detection of brown adipose tissue based on PET imaging [ Time Frame: 1 year ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age 18-30 yrs
  • BMI < 24 kg/m2
  • Caucasian

Exclusion Criteria:

  • Current neuro-psychiatric illness
  • substance abuse
  • medical or neurological illnesses likely to affect physiology or anatomy, i.e., uncontrolled hypertension, cardiovascular disorders
  • current pregnancy
  • current breast feeding
  • suicidal ideation or behavior
  • use of medications which potentially affect NET binding within 2 weeks of the PET scans.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02038595


Locations
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United States, Connecticut
Yale University
New Haven, Connecticut, United States, 06510
Sponsors and Collaborators
Yale University
NYU Langone Health
Investigators
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Principal Investigator: Robert Sherwin, MD Yale University
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Yale University
ClinicalTrials.gov Identifier: NCT02038595    
Other Study ID Numbers: 1008007284
First Posted: January 16, 2014    Key Record Dates
Last Update Posted: March 30, 2020
Last Verified: July 2015
Keywords provided by Yale University:
brown adipose tissue