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What is in Fact the Contribution of Reducing Time Spent in Sedentary Behaviors on Daily Energy Expenditure? A Doubly Labeled Water Study

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ClinicalTrials.gov Identifier: NCT02007681
Recruitment Status : Completed
First Posted : December 11, 2013
Last Update Posted : December 11, 2013
Sponsor:
Information provided by (Responsible Party):
Analiza M Silva, PhD, Technical University of Lisbon

Brief Summary:
The main purposes of this randomized cross-over trial are to test if a 3h/day reduction of time spent in sedentary behaviour (SB) through breaking up hourly and shifting it for standing and walking behaviours would substantially increase total (TEE) and PA energy expenditure (PAEE) compared to a week of habitual prolonged SB, in male and female overweight/obese inactive (which do not attained MVPA recommendations) and sedentary desk workers. Specifically using an experiment design our main aims are: a) to determine the impact of reducing SB on TEE and PAEE; b) to analyse the independent effects of interrupting SB through breaks and the overall reduction in SB on TEE and PAEE; c) To analyse the determinants for the overall reduction in SB; d) If the changes occurred in TEE and PAEE were dependent on specific covariates.

Condition or disease Intervention/treatment Phase
Risk Reduction Behavior Behavioral: Reduction of sedentary time by breaking it with low intensity physical activity Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Effects of Shifting Sedentary Behaviors to Light Activities on Energy Expenditure: A Randomized Controlled Trial in Sedentary Adults
Study Start Date : September 2013
Actual Primary Completion Date : September 2013
Actual Study Completion Date : November 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Lifestyle change
One 5-10 minute break per hour during the work day using a software that alert the participant, and perform 6000 steps above the baseline number of steps/day (previously evaluated), by adopting several domain specific strategies, during 7 days.
Behavioral: Reduction of sedentary time by breaking it with low intensity physical activity
One 5-10 minute break per hour during the work day using a software that alert the participant, and perform 6000 steps above the baseline number of steps/day (previously evaluated), by adopting several domain specific strategies, during 7 days.
Other Names:
  • LIPA
  • breaks

No Intervention: Control
Regular free week with no changes performed



Primary Outcome Measures :
  1. Change from control week and intervention week in total energy expenditure (TEE) [ Time Frame: week 1 and week 2 ]
    The TEE was estimated by the doubly labeled water technique

  2. Resting energy expenditure (REE) [ Time Frame: Baseline (day 0) ]
    REE was measured by indirect calorimetry

  3. Change from control week and intervention week in physical activity energy expenditure (PAEE) [ Time Frame: week 1 and week 2 ]
    PAEE was calculated as the difference between TEE and the sum of the REE and the thermogenic effect of food (assumed to be 10% of TEE)

  4. Change from control week and intervention week in daily time spent in sedentary (SB) [ Time Frame: week 1 and week 2 ]
    PA variables were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart)

  5. Change from control week and intervention week in light (LIPA), moderate and vigorous (MVPA) intensity activities [ Time Frame: week 1 and week 2 ]
    PA variables were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart)

  6. Change from control week and intervention week in number of breaks in sedentary time (BST) [ Time Frame: week 1 and week 2 ]
    PA variables were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart), and an inclinometer (activpal)

  7. Change from control week and intervention week in time spent sitting (TSS) [ Time Frame: week 1 and week 2 ]
    An inclinometer (activpal)

  8. Change from control week and intervention week in time spent standing (TSst) [ Time Frame: week 1 and week 2 ]
    An inclinometer (activpal)

  9. Change from control week and intervention week in time spent walking (TSW) [ Time Frame: week 1 and week 2 ]
    An inclinometer (activpal)

  10. Change from control week and intervention week in number of steps [ Time Frame: week 1 and week 2 ]
    Steps were assessed using an accelerometer, a combined device that measures accelerometry and heart rate (actiheart), an inclinometer (activpal) and a pedometer.


Secondary Outcome Measures :
  1. Change from baseline and intervention week in body composition [ Time Frame: Baseline (day 0) and final day of intervention week ]
    Body composition was assessed by DXA



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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Participants were required to be sedentary, between 18-65 years old, have a BMI above 25.0 kg/m2 and physical inactive (not meeting the MVPA recommendations and not exceed 6000 steps/day). In addition subjects had to be free of any major disease with a general healthy status warranted.

Exclusion Criteria:

  • Taking any medication or dietary supplements that may interfere with body composition or energy expenditure regulation, performing more than 5000 steps/day and meeting actual MVPA recommendations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02007681


Locations
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Portugal
Exercise and Health Laboratory, Faculty of Human Kinetics, University of Lisboa
Cruz Quebrada, Lisboa, Portugal, 1495
Sponsors and Collaborators
Technical University of Lisbon
Investigators
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Principal Investigator: Analiza M Silva, PhD Faculty of Human Kinetics, University of Lisboa
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Analiza M Silva, PhD, Analiza M Silva, Technical University of Lisbon
ClinicalTrials.gov Identifier: NCT02007681    
Other Study ID Numbers: CEFMH || Parecer 14/2013
First Posted: December 11, 2013    Key Record Dates
Last Update Posted: December 11, 2013
Last Verified: December 2013
Keywords provided by Analiza M Silva, PhD, Technical University of Lisbon:
Sedentary Behavior; Breaks; Workplace; Energy Expenditure; Physical activity; doubly labeled water