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Postprandial VLDL-TG Metabolism

This study has been completed.
Information provided by (Responsible Party):
Esben Søndergaard, University of Aarhus Identifier:
First received: September 27, 2013
Last updated: May 1, 2017
Last verified: May 2017
In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.

Type 2 Diabetes

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Postprandial VLDL-TG Metabolism

Further study details as provided by Esben Søndergaard, University of Aarhus:

Primary Outcome Measures:
  • VLDL-TG storage in adipose tissue [ Time Frame: 3 hours ]

Secondary Outcome Measures:
  • 18F-THA fractional storage [ Time Frame: 6 Hours ]

Biospecimen Retention:   Samples With DNA
specimen of muscle specimen of adipose tissue

Enrollment: 21
Study Start Date: January 2014
Study Completion Date: August 2015
Primary Completion Date: August 2015 (Final data collection date for primary outcome measure)
Type 2 diabetic men
Age- and weight-matched controls


Ages Eligible for Study:   30 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Males with diabetes from the department´s out-patient clinic. Control group of healthy volunteers

Inclusion Criteria:

  • Written consent

Exclusion Criteria:

  • Known diseases
  • Alcohol abuse
  • Smoker
  • Regular use of medicine
  Contacts and Locations
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Please refer to this study by its identifier: NCT01961024

Department of Endocrinology MEA, Aarhus Hospital
Aarhus C, Please Select, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

Responsible Party: Esben Søndergaard, Post Doc, MD, PhD, University of Aarhus Identifier: NCT01961024     History of Changes
Other Study ID Numbers: ES-0006
Study First Received: September 27, 2013
Last Updated: May 1, 2017

Keywords provided by Esben Søndergaard, University of Aarhus:
VLDL-TG kinetics
Postprandial state
Obesity processed this record on September 21, 2017