Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)
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ClinicalTrials.gov Identifier: NCT01947361
Verified September 2013 by Harry Hemingway, University College, London. Recruitment status was: Active, not recruiting
: September 20, 2013
Last Update Posted
: September 20, 2013
University College, London
National Institute for Health Research, United Kingdom
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
Risk of atherosclerotic disease in patients with high or low heart rate [ Time Frame: Participants were followed until the first Coronary disease event (an expected average of 5 years) ]
Hazard ratios will be also presenting associations between heart rate and initial presentation of different cardiovascular diseases. These associations will be also measured between different levels of heart rate and CVDs stratified by:
a range of risk factors (such as physical activity, smoking status, drinking status, etc.)
Secondary Outcome Measures
Incidence proportions and life time risk for Cardiovascular diseases [ Time Frame: Participants were followed until the first Coronary disease event (an expected average of 5 years) ]
Subhazard Ratios and Cumulative Incidence estimation of the risk of 12 different cardiovascular diseases adjusted for the 4 different levels of heart rate (<60, 60-74, 75-89, >90), age and sex in a lifetime period
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Ages Eligible for Study:
30 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
1,96 million patients registered in Clinical Practice Research Datalink (CPRD) practices
One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
> 30 years old
have at least a recorded heart rate measurement during the study period
- Evidence of prior atherosclerotic or cardiac disease