Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients
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|ClinicalTrials.gov Identifier: NCT01935388|
Recruitment Status : Completed
First Posted : September 5, 2013
Last Update Posted : October 7, 2016
Many hospitals employ a common canister inhaler protocol in patients that do not require mechanical ventilator support. Common canister refers to a single inhaler paired with standardized cleaning methods for use on more than one patient. Small reports suggest that this method does not pose an increased infectious risk and is associated with significant cost savings.
Common canister protocols offer a solution to the discordance between inhaler sizes and average inpatient use of the drugs. Metered dose inhaler canisters are contain enough drug for several days to weeks of daily use. However, the average length of stay for most inpatients is only several days. Therefore, most inpatients do not use all of the canister contents, an unused resource that is potentially wasted.
The common canister approach has not been previously described in mechanically ventilated patients (people requiring intensive care unit admission on breathing machines). This study aims to assess the safety of common canister utilization by assessment and comparison of infection rates in the study and control group.
|Condition or disease||Intervention/treatment||Phase|
|Ventilator Associated Pneumonia||Other: Common canister||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||354 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Common Canister Protocol for Metered Dose Inhaler Administration in Mechanically Ventilated Patients|
|Study Start Date :||June 2013|
|Actual Primary Completion Date :||February 2016|
|Actual Study Completion Date :||March 2016|
Experimental: Common canister
Use of a single MDI (instead of assigning each patient an individual MDI) for multiple mechanically ventilated patients. Inhalers will undergo a stringent cleaning protocol between administrations and storage.
Other: Common canister
Drug administration via a shared canister with a standardized cleaning protocol.
No Intervention: Control
Each patient will be assigned an individual inhaler as per standard of care practice.
- Ventilator-associated pneumonia (VAP) [ Time Frame: 48 hours after intubation ]Pneumonia that developed in association with mechanical ventilation
- Inhaler drug cost [ Time Frame: During period of mechanical ventilation, which varies depending on patient's severity of illness and reason for intubation; on average may range from 3-5 days. ]Inhaler charges accrued during mechanical ventilation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01935388
|United States, Missouri|
|Saint Louis, Missouri, United States, 63110|
|Principal Investigator:||Marin Kollef, MD||Washington University School of Medicine|