We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Effect of Partial Sleep Deprivation on Immunological System in Peripheral Blood

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01930279
Recruitment Status : Unknown
Verified August 2013 by ayman abu rmaileh, Hadassah Medical Organization.
Recruitment status was:  Not yet recruiting
First Posted : August 28, 2013
Last Update Posted : August 28, 2013
Sponsor:
Information provided by (Responsible Party):
ayman abu rmaileh, Hadassah Medical Organization

Brief Summary:

Sleep deprivation was found to affect many organs including the immune system and predisposing for various health consequences including diabetes hypertension infections and increase in neoplastic diseases.

Subjects will be evaluated for immune parameters in peripheral blood test following a regular nigh sleep and compared with a test performed following a night shift in which they slept less than 3 hours.

Each participant will serve as its own control.


Condition or disease Intervention/treatment
Sleep Deprivation Other: Blood withdrawal

Detailed Description:

Overall Study Design and Plan

  1. Subjects will be bled on the day of the experiment between 8and 9 AM.
  2. Blood tubes will be tested for T cell markers, serum cytokines levels, and other immune parameters by western blots.
  3. The first tube will be tested on the day of experiment.
  4. The second tube will kept in the lab and will be tested 24 hours later.
  5. The third tube will be kept in the pocket of the subject and be tested 24 hours later.
  6. The fourth tube will be kept in the pocket of another subject and will be tested 24 hours later.
  7. The subject will be tested again following 24 hours.
  8. Each subject will be tested twice following a regular 6-8 hours of sleep, and following an on call duty in which he slept less than 3 hours.

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Sleep Deprivation on Expression of T Cell Markers in Peripheral Blood of Medical Residents
Study Start Date : September 2013
Estimated Primary Completion Date : September 2014
Estimated Study Completion Date : September 2014

Group/Cohort Intervention/treatment
surface markers on T cells as assessed by FACS Other: Blood withdrawal
Blood withdrawal



Primary Outcome Measures :
  1. surface markers of T cell as assessed by FACS [ Time Frame: 6 months ]
  2. serum cytokine levels [ Time Frame: 6 months ]
  3. immune parameters to be assessed by western including STAT proteins [ Time Frame: 6 months ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Medical residnets
Criteria

Inclusion Criteria:

Male and female ages 18-40 signed confirmed consent no evidence of chronic disease or chronic medications

Exclusion Criteria:

Any type of acute infection or other acute illness


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01930279


Contacts
Contact: Ayman Abu rmeileh, MD 0584400010 ext 00972 aymansar@gmail.com
Contact: Tawfik Khoury, MD 0509870611 ext 00972 taufick@hadassah.org.il

Locations
Israel
Hadassah Medical Organization Not yet recruiting
Jerusalem, Israel, 91120
Contact: Ayman Abu Rmeileh, MD    0584400010 ext 00972    aymansar@gmail.com   
Contact: Tawfik Khoury, MD    0509870611 ext 00972    taufick@hadassah.org.il   
Sponsors and Collaborators
Hadassah Medical Organization

Responsible Party: ayman abu rmaileh, MD, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT01930279     History of Changes
Other Study ID Numbers: LDB001
First Posted: August 28, 2013    Key Record Dates
Last Update Posted: August 28, 2013
Last Verified: August 2013

Keywords provided by ayman abu rmaileh, Hadassah Medical Organization:
T cell markers

Additional relevant MeSH terms:
Sleep Deprivation
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders