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The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Stephen Patterson, St Mary's University College
ClinicalTrials.gov Identifier:
NCT01907841
First received: July 15, 2013
Last updated: March 5, 2014
Last verified: March 2014
  Purpose

Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.

Therefore the purpose of this study is to:

  1. Quantify the use of IPC in recovery following EIMD.
  2. Identify any effect of IPC during recovery on muscle function

Condition Intervention
Exercise-induced Muscle Damage
Other: Ischemic Preconditioning

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage: a Randomized Control Trial

Resource links provided by NLM:


Further study details as provided by St Mary's University College:

Primary Outcome Measures:
  • Change from baseline in maximal voluntary contraction [ Time Frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise ]

    Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition.

    The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.



Secondary Outcome Measures:
  • Change from baseline in Creatine kinase [ Time Frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise ]

    Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser.

    The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions


  • Change from baseline in Limb girth [ Time Frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise ]

    Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position.

    The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions


  • Chnage from baseline in Vertical jump [ Time Frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise ]

    Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally.

    The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions


  • Change from baseline in Muscle soreness [ Time Frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise ]

    Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful).

    The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions



Estimated Enrollment: 24
Study Start Date: July 2013
Study Completion Date: November 2013
Primary Completion Date: November 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Ischemic Preconditioning
IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials.
Other: Ischemic Preconditioning
Placebo Comparator: Ischemic Preconditioning Placebo
Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle
Other: Ischemic Preconditioning

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Physically Active Males

Exclusion Criteria:

  • Muscular skeletal disorders
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01907841

Locations
United Kingdom
St Marys Umiversity College
London, United Kingdom, TW1 4SX
Sponsors and Collaborators
St Mary's University College
  More Information

Responsible Party: Stephen Patterson, Senior Lecturer Exercise Physiology, St Mary's University College
ClinicalTrials.gov Identifier: NCT01907841     History of Changes
Other Study ID Numbers: IPCEIMD001
Study First Received: July 15, 2013
Last Updated: March 5, 2014

Keywords provided by St Mary's University College:
Investigate IPC on EIMD

ClinicalTrials.gov processed this record on March 24, 2017