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Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Nam-Jong Paik, Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier:
NCT01877161
First received: March 11, 2013
Last updated: June 26, 2017
Last verified: June 2017
  Purpose
Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.

Condition Intervention
To Healthy Volunteer Virtual Lesions for Aphasia Device: Repetitive magnetic stimulation to superior temporal gyrus Device: Repetitive magnetic stimulation to middle temporal gyrus Device: Repetitive magnetic stimulation (Sham)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

Resource links provided by NLM:


Further study details as provided by Nam-Jong Paik, Seoul National University Bundang Hospital:

Primary Outcome Measures:
  • The Change of Reaction Time Between Before and After Stimulation in Each Session (MTG, STG, Sham) [ Time Frame: change between before and after the TMS stimulation for each sessions (at session 1, session 2, session 3) ]

    Reaction time for lexical and repetition test were measured before and after the TMS stimulation at each sessions (at session 1, session 2, session 3 over MTG/STG/Sham; MTG: middle temporal gyrus, STG: superior temporal gyrus).

    Response times were measured via the response pad, and spoken responses were recorded via a SV-1 Voice Key apparatus.

    The "reaction time post TMS - reaction time pre TMS" were used for analysis.* Arm/Group Title Arm/Group Description Maximum length (999) Repetitive magnetic stimulation (rTMS) were applied over STG



Enrollment: 12
Study Start Date: December 2012
Study Completion Date: May 2013
Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Middle temporal gyrus
Repetitive magnetic stimulation to middle temporal gyrus
Device: Repetitive magnetic stimulation to middle temporal gyrus
Repetitive magnetic stimulation to middle temporal gyrus
Other Name: MagPro X100 magnetic stimulator
Sham Comparator: Control group
Repetitive magnetic stimulation (Sham)
Device: Repetitive magnetic stimulation (Sham)
Repetitive magnetic stimulation (Sham)
Other Name: MagPro X100 magnetic stimulator
Experimental: Superior temporal gyrus
Repetitive magnetic stimulation to superior temporal gyrus
Device: Repetitive magnetic stimulation to superior temporal gyrus
Repetitive magnetic stimulation to superior temporal gyrus
Other Name: MagPro X100 magnetic stimulator

Detailed Description:
To evaluate the effect of navigated repetitive transcranial magnetic stimulation in subjects with aphasia after stroke.
  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • fluent in Korean
  • older than 18 years old

Exclusion Criteria:

  • younger than 18 years old
  • psychotic or psychiatric problems
  • pregnant
  • contraindications to MRI/fMRI
  • uncooperative
  • metalic implants, pacemaker or cochlear implants
  • cannot perform outcome measure-related task
  • known seizure history
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01877161

Locations
Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Bundang-gu, Korea, Republic of, 463-707
Sponsors and Collaborators
Seoul National University Bundang Hospital
Investigators
Principal Investigator: Nam-Jong Paik, MD, PhD Seoul National University Bundang Hospital
  More Information

Responsible Party: Nam-Jong Paik, Professor, Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier: NCT01877161     History of Changes
Other Study ID Numbers: E-1206-158-003
Study First Received: March 11, 2013
Results First Received: January 23, 2014
Last Updated: June 26, 2017

Additional relevant MeSH terms:
Aphasia
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on September 18, 2017