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Human Irisin Concentration in Sarcopenia

This study has been completed.
Information provided by (Responsible Party):
K. M. Choi, Korea University Identifier:
First received: June 3, 2013
Last updated: June 7, 2013
Last verified: June 2013
Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, the researches investigated whether serum irisin levels are decreased in patients with sarcopenia compared with control subjects with normal muscle mass, and assessed the association between serum irisin levels and various metabolic parameters.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional

Further study details as provided by K. M. Choi, Korea University:

Primary Outcome Measures:
  • Serum concentration of irisin in the subjects with sarcopenia [ Time Frame: 12 week ]

Secondary Outcome Measures:
  • The relationship of serum irisin levels with lipid profiles [ Time Frame: 12 week ]
  • The relationship of serum irisin levels with skeletal muscle mass index [ Time Frame: 12 wks ]

Enrollment: 406
Study Start Date: November 2009
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients in Korean Sarcopenic Obesity Study (KSOS), an prospective observational cohort study designed to examine the prevalence of sarcopenia and sarcopenic obesity in Korean adults and to evaluate their effects on metabolic disorders and health outcomes.

Inclusion Criteria:

  • 20<age<80
  • apparently healthy subjects

Exclusion Criteria:

  • a history of cardiovascular disease
  • diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01874912

Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: K. M. Choi, Professor, Korea University Identifier: NCT01874912     History of Changes
Other Study ID Numbers: SO(IRISIN)
Study First Received: June 3, 2013
Last Updated: June 7, 2013

Additional relevant MeSH terms:
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Pathological Conditions, Anatomical
Signs and Symptoms processed this record on September 21, 2017