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Human Irisin Concentration in Sarcopenia

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ClinicalTrials.gov Identifier: NCT01874912
Recruitment Status : Completed
First Posted : June 11, 2013
Last Update Posted : June 11, 2013
Sponsor:
Information provided by (Responsible Party):
K. M. Choi, Korea University

Brief Summary:
Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, the researches investigated whether serum irisin levels are decreased in patients with sarcopenia compared with control subjects with normal muscle mass, and assessed the association between serum irisin levels and various metabolic parameters.

Condition or disease
Sarcopenia

Study Type : Observational
Actual Enrollment : 406 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Study Start Date : November 2009
Actual Primary Completion Date : April 2011
Actual Study Completion Date : April 2011



Primary Outcome Measures :
  1. Serum concentration of irisin in the subjects with sarcopenia [ Time Frame: 12 week ]

Secondary Outcome Measures :
  1. The relationship of serum irisin levels with lipid profiles [ Time Frame: 12 week ]
  2. The relationship of serum irisin levels with skeletal muscle mass index [ Time Frame: 12 wks ]


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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients in Korean Sarcopenic Obesity Study (KSOS), an prospective observational cohort study designed to examine the prevalence of sarcopenia and sarcopenic obesity in Korean adults and to evaluate their effects on metabolic disorders and health outcomes.
Criteria

Inclusion Criteria:

  • 20<age<80
  • apparently healthy subjects

Exclusion Criteria:

  • a history of cardiovascular disease
  • diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01874912


Locations
Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: K. M. Choi, Professor, Korea University
ClinicalTrials.gov Identifier: NCT01874912     History of Changes
Other Study ID Numbers: SO(IRISIN)
First Posted: June 11, 2013    Key Record Dates
Last Update Posted: June 11, 2013
Last Verified: June 2013

Additional relevant MeSH terms:
Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms