The Effects of Exercise in Parkinson's Disease (PET)
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|ClinicalTrials.gov Identifier: NCT01835652|
Recruitment Status : Completed
First Posted : April 19, 2013
Last Update Posted : March 17, 2021
|Condition or disease||Intervention/treatment||Phase|
|Parkinson Disease 10||Other: Active Exercise Other: Passive Exercise||Not Applicable|
The purpose of this study is to determine the basis for symptomatic and disease modifying benefits of exercise in Parkinson's disease (PD).
Although the benefits of exercise in PD have been purported for several decades, only recently have there been controlled reports of symptomatic benefits in Parkinson's disease in terms of bradykinesia, postural balance and quality of life. There have been unsubstantiated suggestions that exercise may improve cognition and mood in PD.
The mechanisms underlying such benefits are poorly understood. Exercise may induce dopamine release, thereby contributing to improved motor function in the dorsal striatum, and to enhanced mood and reduced apathy in the ventral striatum.
We will test the hypotheses that exercise results in altered synaptic plasticity in the form of altered connectivity in response to aerobic exercise and reward-induced dopamine release. We will assess networks of functional connectivity using functional magnetic resonance imaging and measure dopamine release with positron emission tomography (PET).
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||18 participants|
|Intervention Model:||Parallel Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||The Effects of Exercise in Parkinson's Disease.|
|Study Start Date :||April 2013|
|Actual Primary Completion Date :||March 2015|
|Actual Study Completion Date :||March 2015|
Active Comparator: Active Exercise
Aerobic Exercise Intervention (stationary cycling)
Other: Active Exercise
Passive Exercise (stretching and balance based exercise)
Other: Passive Exercise
- PET [ Time Frame: 3 months ]Dopamine release will be assessed using positron emission tomography (PET)
- fMRI [ Time Frame: 3 months ]fMRI will be performed to record response to rewarding stimuli
- Clinical Measures [ Time Frame: 3 months ]Motor function will be assessed using the MDS-Unified Parkinson's Disease Rating Scale, finger tapping and Purdue Pegboard. Cognitive function will be assessed using the Montreal Cognitive Assessment, Wisconsin Card-Sorting Task, Trail-Making B Test and a computerized reaction time test. Mood and apathy will be assessed using the Beck Depression Inventory and Starkstein Apathy Scale.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01835652
|Canada, British Columbia|
|Pacific Parkinson's Research Centre|
|Vancouver, British Columbia, Canada, V6T 2B5|
|Study Director:||Jessamyn McKenzie||Pacific Parkinson's Research Centre|