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Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm

This study has been terminated.
(Low enrollment)
Sponsor:
ClinicalTrials.gov Identifier:
NCT01801488
First Posted: February 28, 2013
Last Update Posted: November 25, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
State University of New York - Upstate Medical University
  Purpose
Test single nucleotide polymorphisms (SNP's) in ruptured and unruptured aneurysm tissue to identify a genetic difference between the two types of aneurysms; and to test SNP's in arteriovenous malformation tissue to identify a genetic link.

Condition
Arteriovenous Malformations Intracranial Aneurysm Subarachnoid Hemorrhage

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm

Resource links provided by NLM:


Further study details as provided by State University of New York - Upstate Medical University:

Primary Outcome Measures:
  • Risk gene expression [ Time Frame: Within one week of sample collection. ]
    The samples will be frozen after collection and then analyzed.


Biospecimen Retention:   Samples With DNA
Tissue samples of intracranial arterial-venous malformations (AVM) or aneurysm and blood samples.

Enrollment: 5
Study Start Date: November 2011
Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
AVM Patients
Patients receiving surgical intervention for an intracranial arterial-venous malformation.
Ruptured Aneurysm
Patients receiving surgical intervention for a ruptured intracranial aneurysm.
Unruptured Aneurysm
Patients receiving surgical intervention for an unruptured intracranial aneurysm.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients admitted to University Hospital.
Criteria

Inclusion Criteria:

  • All adult patients between the ages of 18 and 89 that are having open surgical resection of an AVM or clipping of an aneurysm will be included

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01801488


Locations
United States, New York
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Sponsors and Collaborators
State University of New York - Upstate Medical University
Investigators
Principal Investigator: Eric M Deshaies, MD SUNY Upstate Medical University Neurosurgery
  More Information

Responsible Party: State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier: NCT01801488     History of Changes
Other Study ID Numbers: IRB#238810
First Submitted: December 12, 2012
First Posted: February 28, 2013
Last Update Posted: November 25, 2015
Last Verified: February 2013

Additional relevant MeSH terms:
Hemorrhage
Aneurysm
Subarachnoid Hemorrhage
Congenital Abnormalities
Intracranial Aneurysm
Arteriovenous Malformations
Hemangioma
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Intracranial Hemorrhages
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Intracranial Arterial Diseases
Vascular Malformations
Cardiovascular Abnormalities
Neoplasms, Vascular Tissue
Neoplasms by Histologic Type
Neoplasms