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Determining the Association of Chromosomal Variants With Non-PV Triggers and Ablation-outcome in AF (DECAF) (DECAF)

This study has been completed.
University of Texas at Austin
Information provided by (Responsible Party):
Andrea Natale, Texas Cardiac Arrhythmia Research Foundation Identifier:
First received: December 11, 2012
Last updated: September 4, 2014
Last verified: September 2014
This prospective study aims to examine the association of specific genetic variants (single nucleotide polymorphisms) located on chromosome 1, 4 and 16, with presence of non-pulmonary vein triggers (NPVT) as well as ablation-outcome in AF patients

Condition Phase
Atrial Fibrillation
Phase 3

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Determining the Association of Chromosomal Variants With Non-PV Triggers and Ablation-outcome in AF (DECAF)

Resource links provided by NLM:

Further study details as provided by Texas Cardiac Arrhythmia Research Foundation:

Primary Outcome Measures:
  • PVAI and isolation of all non-PV triggers [ Time Frame: 1 hour of the ablation procedure ]
    Isolation of pulmonary-vein antra and all extra-pulmonary vein triggers

Secondary Outcome Measures:
  • Recurrence of arrhythmia [ Time Frame: Within 1 year of follow-up ]
    Recurrence will be defined as freedom from atrial flutter (AFL), AF or atrial tachycardia (AT) of > 30 seconds duration, in the absence of anti-arrhythmic drugs (AADs) at follow-up.

Biospecimen Retention:   Samples With DNA
Blood samples will be collected from which DNA would be extracted for SNP analysis

Enrollment: 400
Study Start Date: December 2012
Study Completion Date: August 2014
Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
genetic variants
AFib patients with or without the genetic variants

  Show Detailed Description


Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients with atrial fibrillation

Inclusion Criteria:

  1. Age ≥ 18 years
  2. AF patients undergoing catheter ablation
  3. Able and willing to provide written informed consent

Exclusion Criteria:

  1. Previous left atrial catheter ablation or MAZE procedure
  2. Reversible causes of atrial arrhythmia such as hyperthyroidism, sarcoidosis, pulmonary embolism etc
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01751607

United States, Texas
Texas Cardiac Arrhythmia Institute, St. david's Medical Center
Austin, Texas, United States, 78705
Texas Cardiac arrhythmia Institute, St. David's Hospital
Austin, Texas, United States
Sponsors and Collaborators
Texas Cardiac Arrhythmia Research Foundation
University of Texas at Austin
Study Director: Andrea Natale, MD TCAI
Principal Investigator: Mitra Mohanty, MD TCAI
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Andrea Natale, Executive Medical Director, Texas Cardiac Arrhythmia Research Foundation Identifier: NCT01751607     History of Changes
Other Study ID Numbers: TCAI_DECAF
Study First Received: December 11, 2012
Last Updated: September 4, 2014

Keywords provided by Texas Cardiac Arrhythmia Research Foundation:
AF, catheter ablation, non-PV triggers, SNP

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes processed this record on May 25, 2017