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Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01719068
Recruitment Status : Unknown
Verified October 2012 by British Columbia Cancer Agency.
Recruitment status was:  Recruiting
First Posted : November 1, 2012
Last Update Posted : November 1, 2012
BC Cancer Foundation
Information provided by (Responsible Party):
British Columbia Cancer Agency

Brief Summary:
This is a pilot study that aims to develop a lung cancer screening program for workers in British Columbia, Canada exposed to asbestos who are at risk of developing lung cancer/pleural mesothelioma. This is high risk population is at of respiratory system diseases as a result of their occupational exposures. Additionally, knowledge garnered from this study will allow us to develop other studies that will further our understanding of asbestos related lung cancer and mesothelioma.

Condition or disease
Mesothelioma Lung Cancer

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Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos
Study Start Date : October 2012
Estimated Primary Completion Date : October 2014
Estimated Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

Workers exposed to asbestos

Primary Outcome Measures :
  1. Development of Model to Predict Workers at highest risk of lung cancer/mesothelioma [ Time Frame: 3 years ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   50 Years to 79 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Workers in British Columbia who have been exposed to asbestos.

Inclusion Criteria:

  • Women or men age 50 to 79 years
  • history of exposure to asbestos at work and one or more of the following:

    • lung cancer risk ≥2% over 3 years or
    • asbestosis or pleural plaques on a chest x-ray or
    • abnormal auto-antibodies level using the EarlyCDT test
  • Capable of providing informed consent for screening procedures (low dose spiral CT, lung function, blood biomarkers).

Exclusion Criteria:

  • Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, or any disorder, that in the opinion of the physician unlikely to benefit from screening due to shortened life-expectancy from co-existing illnesses
  • Have been previously diagnosed with mesothelioma
  • Have had other cancer within the past 5 years with the exception of the following cancers: non-melanomatous skin cancer,localized prostate cancer, carcinoma in situ (CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must have ended >6 months before registration into this study
  • Pregnancy
  • Unwilling to have a low dose CT scan of chest
  • Unwilling to sign a consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01719068

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Contact: Sharon Gee 604-675-8089

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Canada, British Columbia
British Columbia Cancer Agency Recruiting
Vancouver, British Columbia, Canada, V5Z1L3
Contact: Sharon Gee    604-675-8089   
Principal Investigator: Stephen Lam, MD         
Sub-Investigator: Annette McWilliams, MD         
Sub-Investigator: Tawimas Shaipanich, MD         
Sponsors and Collaborators
British Columbia Cancer Agency
BC Cancer Foundation
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Principal Investigator: Stephen Lam British Columbia Cancer Agency
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Responsible Party: British Columbia Cancer Agency Identifier: NCT01719068    
Other Study ID Numbers: H12-01812
First Posted: November 1, 2012    Key Record Dates
Last Update Posted: November 1, 2012
Last Verified: October 2012
Keywords provided by British Columbia Cancer Agency:
Lung Cancer
Early Detection
Additional relevant MeSH terms:
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Lung Neoplasms
Mesothelioma, Malignant
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms, Mesothelial
Pleural Neoplasms