Neural Components Underlying the Treatment of Adolescent Depression
The goal of the study is to examine how cognitive behavioral therapy (CBT), a common treatment for adolescent depression, affects brain functioning. Depressed adolescents will complete an initial assessment consisting of an interview, questionnaires, computer tasks, and an EEG recording. EEG (electroencephalography) measures brain activity by recording the electrical activity along the scalp caused by the firing of neurons within the brain. They will then complete 12 sessions of cognitive behavioral therapy, which will be 50 minutes long and held once a week for 12 weeks. Before their third therapy session, participants will complete a computer task while EEG data are recorded. After completing the treatment, the participants will complete a final assessment, which will include questionnaires, computer tasks, and an EEG recording. They will also complete follow-up assessments over the phone 1, 3, and 6 months after completing the treatment.
This study will also include healthy control participants. They will complete an initial assessment consisting of an interview, questionnaires, computer tasks, and an EEG recording. Three weeks later, they will return to complete a behavioral task while EEG data are recorded. Twelve weeks after the initial assessment, they will complete a final assessment, which will include questionnaires, computer tasks, and an EEG recording.
|Study Design:||Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Examination of the Neural Components Underlying the Treatment of Adolescent Major Depression|
- EEG Activity [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]EEG and ERP measures collected during resting state and behavioral tasks
|Study Start Date:||October 2012|
|Estimated Primary Completion Date:||June 2018 (Final data collection date for primary outcome measure)|
Cognitive Behavioral Therapy
12 weekly sessions of cognitive behavioral therapy
Behavioral: Cognitive Behavioral Therapy
12 sessions of cognitive behavioral therapy
|No Intervention: Healthy Controls|
The purpose of the study is to examine the impact of individual cognitive behavioral therapy (CBT) for adolescent depression on neural functioning. Specifically, the study will utilize Brent and Poling's (1997) cognitive behavioral therapy (CBT) manual (Cognitive Therapy Treatment Manual for Depressed and Suicidal Youth), and investigators will examine pre- to post- neural activity patterns for children and adolescents who receive individual CBT for depression. Electroencephalography (EEG) techniques will be utilized to assess treatment-related effects on brain activity (i.e., anterior cingulate cortex and dorsolateral prefrontal cortex functioning). Neural activity patterns will also be compared to non-depressed, healthy controls.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01717508
|Contact: Colin Stantonfirstname.lastname@example.org|
|United States, Massachusetts|
|Belmont, Massachusetts, United States, 02478|
|Contact: Colin Stanton 617-855-4240 email@example.com|
|Principal Investigator:||Randy P Auerbach, PhD||Mclean Hospital|