Efficacy of High Flow Nasal Cannula Oxygen to Reduce Desaturation During Tracheal Intubation (HAPI)
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ClinicalTrials.gov Identifier: NCT01699880 |
Recruitment Status :
Completed
First Posted : October 4, 2012
Last Update Posted : August 12, 2014
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Condition or disease |
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Need for Intubation Oxygenation Before and During Intubation |
Study Type : | Observational |
Actual Enrollment : | 101 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | High Flow Nasal Cannula Oxygen for Pre and During Procedure Oxygenation During Tracheal Intubation: Comparison With High FiO2 Non Rebreathing Bag Reservoir Facemasks |
Study Start Date : | March 2011 |
Actual Primary Completion Date : | November 2012 |
Actual Study Completion Date : | January 2013 |

Group/Cohort |
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conventional high FiO2 bag reservoir facemask
this group of patients is intubated according to our current practice that requires the use of a high FiO2 nonrebreathing with bag reservoir facemask to ensure preoxygenation in patients requiring tracheal intubation. a small nasal catheter is inserted just before laryngoscopy to ensure a low oxygen flow to allow oxygenation during laryngoscopy.
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high flow nasal cannula oxygen
we wish to change our standard practice of preoxygenation and expand our use of high flow nasal cannula oxygen therapy to the tracheal intubation setting. Currently, used of high flow oxygen nasal cannula oxygen therapy to ensure oxygenation during intubation is limited to the patients already under high flow nasal cannula oxygen. the change of practice consists in the systematic use of high flow nasal cannula oxygen therapy in all patients requiring tracheal intubation in the ICU.
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- lowest pulse oxymetry (SpO2) during intubation [ Time Frame: from beginning of laryngoscopy to completed intubation ]
- mean pulse oxymetry during intubation [ Time Frame: from beginning of laryngoscopy to completed intubation ]
- pulse oxymetry after preoxygenation [ Time Frame: 3min prexoxygenation ]
- pulse oxymetry after intubation [ Time Frame: at connection of the patient to the ventilator ]
- mean pulse oxymetry [ Time Frame: one, five and thirty minutes after intubation ]
- number of pulse oxymetry below 90% [ Time Frame: from laryngoscopy to 30 minutes once tracheal intubation completed ]
- number of pulse oxymetry below 80% [ Time Frame: from laryngoscopy to 30 minutes once tracheal intubation completed ]
- cardiac arrest [ Time Frame: during and immediately after procedure ]
- hemodynamic instability defined as arterial systolic blood pressure below 80 mmHg [ Time Frame: during and immediately after procedure ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- ICU patient requiring tracheal intubation
Exclusion Criteria:
- age < 18 years
- cardiac arrest
- acute respiratory failure requiring immediate high flow nasal cannula oxygen, defined as patient with SpO2 < 95% while under 15 L:min oxygen with a nonrebreathing facemask

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01699880
France | |
Medico-surgical ICU | |
Colombes, France, 92701 |
Principal Investigator: | Jean-Damien Ricard, MD, PhD | Hopital Louis Mourier, AP-HP, Colombes, France |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Prof Jean-Damien RICARD, Professor of Intensive Care Medicine, assistant head of ICU, Hôpital Louis Mourier |
ClinicalTrials.gov Identifier: | NCT01699880 |
Other Study ID Numbers: |
HLM_JDR1 |
First Posted: | October 4, 2012 Key Record Dates |
Last Update Posted: | August 12, 2014 |
Last Verified: | August 2014 |
tracheal intubation preoxygenation desaturation |
hypoxemia oxygen therapy high flow nasal cannula oxygen therapy |