Working... Menu

Telomere Parameters in Patients With Nonalcoholic Fatty Liver (telomereFL)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01694342
Recruitment Status : Unknown
Verified July 2012 by Meir Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : September 27, 2012
Last Update Posted : September 27, 2012
Information provided by (Responsible Party):
Meir Medical Center

Brief Summary:

Telomerase, through its regulatory function on telomere length may play an important role in immune function, cellular replicative life span, and carcinogenesis. Non-alcoholic fatty liver disease (NAFLD) is considered a benign condition, but in some cases, it may progress to cirrhosis and hepatocellular carcinoma. The risk factors for that evolution are not fully understood.

Our group showed in a previous study, that hTERT mRNA expression is lower in peripheral lymphocytes of patients with fatty liver, compared to healthy controls. This finding could explain the telomere shortening found previously in these patients by our group [20] and others [21]. Furthermore, we found higher rates of TC in these patients, probably due to an attempt to counteract the shortening of the telomeres and to stabilize them. This is through a different mechanism that is not telomerase-mediated.

Telomere capture is considered an alternative way to maintain telomere length and chromosomal stability [3]. It is a more common mechanism for chromosome stabilization and repair, in contrast to the telomerase-mediated process of chromosome healing and elongation This study aimed to evaluate mechanisms of telomere homeostasis like telomere shortening, telomerase activity, telomere capture and aneuploidy in patients with NAFLD in order to explain previous findings of telomere shortening in these patients.

Condition or disease

Layout table for study information
Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Telomere Parameters Like Telomere Length, Telomerase Expression, Telomere Capture and Aneuploidy in Patients With Nonalcoholic Fatty Liver
Study Start Date : September 2012

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Individuals - over 18 years old that were diagnosed with nonalcoholic fatty liver and are on follow-up in our liver unit

Inclusion Criteria:

  • age over 18
  • diagnosis of fatty liver

Exclusion Criteria:

  • no malignancy
  • no eligible to sign the consent paper

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01694342

Layout table for location contacts
Contact: Yona Kitay-Cohen, MD +97297471560

Layout table for location information
Meir Hospital Not yet recruiting
Kefar Saba, Israel
Contact: Yona Kitay-Cohen, MD    +97297471560   
Principal Investigator: Yona Kitay-Cohen, MD         
Sponsors and Collaborators
Meir Medical Center

Layout table for additonal information
Responsible Party: Meir Medical Center Identifier: NCT01694342     History of Changes
Other Study ID Numbers: ramona 1.0
First Posted: September 27, 2012    Key Record Dates
Last Update Posted: September 27, 2012
Last Verified: July 2012

Additional relevant MeSH terms:
Layout table for MeSH terms
Fatty Liver
Non-alcoholic Fatty Liver Disease
Liver Diseases
Digestive System Diseases