Comparison of Two Protocols for Patellofemoral Pain Syndrome (PFPS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01691170
Recruitment Status : Completed
First Posted : September 24, 2012
Last Update Posted : September 25, 2012
Information provided by (Responsible Party):
Gabriel Peixoto Leão Almeida, PT, University of Sao Paulo

Brief Summary:
The patellofemoral pain syndrome (PFPS) is defined as a painful complaint in the anterior aspect of the knee, although peripatellar pain and / or retropatellar are also common. In general, conservative treatment is the initial option of choice for patients with PFPS, however, the lack of a specific causal factor makes it difficult to choose the best treatment so early. This way, the purpose of this study is investigate the effects of the quadriceps femoris strengthening versus hamstring stretching in patients with pattellofemoral pain.

Condition or disease Intervention/treatment Phase
Patellofemoral Pain Syndrome Other: Stretching Hamstring Other: Quadriceps Strengthening Phase 1 Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Quadriceps Femoris Strengthening Versus Hamstring Stretching for Patellofemoral Pain Syndrome: A Randomized Clinical Trial.
Study Start Date : March 2008
Actual Primary Completion Date : February 2011
Actual Study Completion Date : September 2011

Arm Intervention/treatment
Active Comparator: Quadriceps Strengthening Other: Quadriceps Strengthening
Active Comparator: Stretching Hamstring Other: Stretching Hamstring

Primary Outcome Measures :
  1. Numeric Pain Rating Scale [ Time Frame: Participants will be followed for the duration of 8 weeks. ]
    Pain was assessed using an 11-point numeric pain rating scale (NPRS), on which 0 denoted an absence of pain and 10 denoted unbearable pain.

Secondary Outcome Measures :
  1. Lysholm Scale [ Time Frame: Participants will be followed for the duration of 8 weeks. ]
    This questionnaire is made up of eight items with objective response options. The final score is expressed in nominal and ordinal form, as follows: 95 to 100 points - excellent; 84 to 94 points - good; 65 to 83 points - fair; and 64 or fewer points - poor.

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Symptoms of anterior knee pain for at least 1 moth;
  • Average pain level of 3 or more on a 10-cm visual analogue scale during stepping up and down a 25-cm height;
  • Anterior or retropatellar knee pain on at least 2 of the following activities: prolonged sitting, climbing stairs, squatting, running, kneeling, and hopping/jumping;
  • Presence of 2 of the following clinical criteria on assessment: pain during apprehension test, pain during the patellar compression test, and crepitation during the compression test.

Exclusion Criteria:

  • Previous knee surgery or arthritis;
  • History of patellar dislocation or subluxation, malalignment, or ligament laxity;
  • Patellar tendon pathology or chondral damage;
  • Spinal referred pain;
  • History of other abnormalities such as leg length inequalities (>2 cm);
  • Medication as a part of the treatment;
  • Previous physical therapy or acupuncture treatment for the knee within the previous 30 days.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01691170

Physical Therapy, Speech and Occupational Therapy Department, University of São Paulo.
São Paulo, Brazil, 05360-000
Sponsors and Collaborators
University of Sao Paulo

Responsible Party: Gabriel Peixoto Leão Almeida, PT, Principal Investigator, University of Sao Paulo Identifier: NCT01691170     History of Changes
Other Study ID Numbers: USP01
First Posted: September 24, 2012    Key Record Dates
Last Update Posted: September 25, 2012
Last Verified: September 2012

Keywords provided by Gabriel Peixoto Leão Almeida, PT, University of Sao Paulo:
Pattelofemoral pain syndrome

Additional relevant MeSH terms:
Somatoform Disorders
Patellofemoral Pain Syndrome
Pathologic Processes
Mental Disorders
Joint Diseases
Musculoskeletal Diseases