Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection. (TSCORII)
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ClinicalTrials.gov Identifier: NCT01678274 |
Recruitment Status : Unknown
Verified June 2015 by University of Aarhus.
Recruitment status was: Active, not recruiting
First Posted : September 3, 2012
Last Update Posted : May 24, 2016
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Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes affecting 1 of 2000 live born girls. The syndrome is characterized by an increased prevalence of ischemic heart disease, aortic dilation and dissection, hypertension, stroke and autoimmune diseases in general.
Our study aim is:
- Using MRI to further characterize and find risk factors leading to aortic dilation.
- Using MRI to assess the degree of aortic distensibility.
- Using Computed tomography x-ray scanning of the heart and coronary arteries to characterize the prevalence and degree of ischemic heart disease and coronary anomalies.
- Using pressure sensitive ultrasound (applanation tonometry) to assess the degree of aortic stiffness when compared to controls using end points as Pulse Wave Velocity, Augmentation Index and Central Pulse Pressure.
Condition or disease |
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Turner Syndrome Aortic Aneurysm Ischemic Heart Disease Hypertension Congenital Heart Defect |
Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes affecting 1 of 2000 live born girls. The syndrome is characterized by an increased prevalence of ischemic heart disease, aortic dilation and dissection, congenital heart defects, hypertension, stroke, ovarian failure, infertility, decreased final height and autoimmune diseases in general
Our study aim is:
- Using MRI to further characterize and find risk factors leading to aortic dilation.
- Using MRI to describe aortic dimensions
- Using MRI to assess the degree of aortic distensibility.
- Using Computed tomography x-ray scanning of the heart and coronary arteries to characterize the prevalence and degree of ischemic heart disease and coronary anomalies.
- Using pressure sensitive ultrasound (applanation tonometry) to assess the degree of aortic stiffness when compared to controls using end points as Pulse Wave Velocity, Augmentation Index and Central Pulse Pressure.
Study Type : | Observational |
Actual Enrollment : | 106 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Prospective Characterization of the Heart, Aorta and Blood Pressure in Women With Turner Syndrome. Association With Aortic Dissection. |
Study Start Date : | December 2013 |
Actual Primary Completion Date : | March 2016 |
Estimated Study Completion Date : | October 2016 |

Group/Cohort |
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Turner syndrome
Females with Turner syndrome
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Control group
age matched females acting as controls
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- Aortic dimensions [ Time Frame: Once ]Aortic dimensions measured by MRI
- Agatston score [ Time Frame: Once ]Coronary CT evaluation of Agatston score
- Segment involvement score [ Time Frame: Once ]Segment involvement score (SIS) calculated as the sum of segments with one or more coronary plaques (score 0-18).
- Aortic distensibility [ Time Frame: Once ]Aortic distensibillity as measured by MRI
- 24 hour blood pressure [ Time Frame: 24 hour ]24 hour blood pressure
- Pulse Wave Velocity [ Time Frame: Once ]Pulse Wave Velocity measured by applanation tonometry.
- Augmentation index [ Time Frame: Once ]Augmentation index measured by applanation tonometry.
- Central blood pressure [ Time Frame: Once ]Central blood pressure measured by applanation tonometry.
- echocardiography [ Time Frame: Once ]echocardiography evaluating Mitral and aortic valves, left ventricular hypertrophy, diastolic and systolic function etc..
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Ages Eligible for Study: | 18 Years to 90 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Females with Turner Syndrome previously participating in our study number 2001024 are recruited from out-patient clinics.
Controls are healthy volunteers recruited from the general population by advertisement.
Inclusion Criteria with respect to individuals acting as controls:
- Healthy age matched females
Exclusion Criteria:
- Contraindications for MRI
- Contraindications for CT
- Severe obesity
- Acute og Chronic disease with known or presumed significance with concern to outcomes of the study
- Previous or present malignant disease
- Clinically significant liver disease
- Mechanic or biological heart valves

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01678274
Denmark | |
Department of Endocrinology and Internal medicine | |
Aarhus, Denmark, 8000 |
Study Chair: | Claus H Gravholt, MD | Aarhus University Hospital | |
Principal Investigator: | Christian Trolle, MD | Aarhus University Hospital |
Responsible Party: | University of Aarhus |
ClinicalTrials.gov Identifier: | NCT01678274 |
Other Study ID Numbers: |
35202 |
First Posted: | September 3, 2012 Key Record Dates |
Last Update Posted: | May 24, 2016 |
Last Verified: | June 2015 |
Turner Syndrome Aortic Aneurysm Ischemic heart disease Hypertension Congenital Heart Defect |
Pulse Wave Velocity Augmentation Index Central Blood Pressure Agatston Score Segment involvement score |
Turner Syndrome Gonadal Dysgenesis Hypertension Heart Diseases Aneurysm Aortic Aneurysm Myocardial Ischemia Coronary Artery Disease Aneurysm, Dissecting Heart Defects, Congenital Syndrome Disease Pathologic Processes Vascular Diseases Cardiovascular Diseases |
Aortic Diseases Coronary Disease Arteriosclerosis Arterial Occlusive Diseases Disorders of Sex Development Urogenital Abnormalities Sex Chromosome Disorders of Sex Development Cardiovascular Abnormalities Congenital Abnormalities Sex Chromosome Disorders Chromosome Disorders Genetic Diseases, Inborn Gonadal Disorders Endocrine System Diseases |