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ClinicalTrials.gov Identifier: NCT01670396
Verified August 2012 by Shanghai Zhongshan Hospital. Recruitment status was: Recruiting
The investigators hypothesized that genetic variants of G protein influence the development of restenosis and clinical outcome of patients receiving drug-eluting stents (DES).
Condition or disease
Coronary Artery Disease
Although drug-eluting stents (DES) have reduced restenosis rates compared with bare-metal stents, the restenosis rate is still high in the high-risk group. G protein plays important roles in the signal transduction leading to vascular smooth muscle proliferation. The initial and subsequent studies suggest that the T allele of C825T polymorphism is associated with enhanced transmembrane signaling via Gi proteins.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients who underwent follow-up angiography. All the patients must had been implanted with DES during the last two years.
For the non-ISR group, the patients underwent follow-up angiography less than 6 months away from stent implanting.