Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance
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|ClinicalTrials.gov Identifier: NCT01668368|
Recruitment Status : Unknown
Verified August 2012 by Soroksky Arie, Wolfson Medical Center.
Recruitment status was: Not yet recruiting
First Posted : August 20, 2012
Last Update Posted : August 20, 2012
|Condition or disease||Intervention/treatment||Phase|
|Acute Respiratory Failure ARDS||Other: esophageal balloon||Not Applicable|
Identifying the dominant factor affecting respiratory system compliance by measuring transpulmonary pressure may better direct and optimize mechanical ventilation. Thus, instead of limiting mechanical ventilation by plateau pressure, PEEP and Inspiratory pressure adjustment would be individualized specifically for each patient's lung compliance as indicated by transpulmonary pressure.
The main goal of this approach is to specifically target transpulmonary pressure instead of plateau pressure, and therefore achieve the best Lung compliance with the least transpulmonary pressure possible.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance Approach Guided by Esophageal Pressure in Acute Respiratory Failure.|
|Study Start Date :||September 2012|
|Estimated Primary Completion Date :||September 2013|
|Estimated Study Completion Date :||September 2013|
Esophageal balloon group
Esophageal balloon will be inserted, and esophageal pressure will be measured in patients with acute respiratory failure.
Intervention - PEEP and Inspiratory pressure will be adjusted according to the measured esophageal pressure.
Other: esophageal balloon
esophageal pressure as a surrogate for pleural pressure
Other Name: pleural pressure
- Oxygenation [ Time Frame: 1 year ]
- lung compliance, expressed as ml/cmH2O. [ Time Frame: 1 year ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01668368
|Contact: Arie Soroksky, M.D.||firstname.lastname@example.org|
|Principal Investigator:||Arie Soroksky, MD||Wolfson MC|