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Water Exercise and Vascular Function in Elderly

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01642654
Recruitment Status : Completed
First Posted : July 17, 2012
Last Update Posted : July 17, 2012
Information provided by (Responsible Party):
Yula Pires da Silveira Fontenele de Meneses, Universidade Federal do Rio Grande do Norte

Brief Summary:


The purpose of this research was to assess modifications caused by a concurrent water exercise program on plasma nitrite (NO3), cerebral vascular resistance and cholesterol in the elderly and analyze the correlations between these variables after intervention.

Methods The sample was composed of 40 women mean age 69,21 ±5,27 years old, divided into an intervention (WG) and control group (CG). It was to measure nitrite concentration (NO3) by the Griess reaction; internal cerebral arteries were assessed by Doppler ultrasound to determine the resistivity index and Cholesterol was determined using the colorimetric enzymatic method and test kit. Intervention with water exercise program consisted of three weekly sessions for 16 weeks.

Condition or disease Intervention/treatment Phase
Elderly Women Other: Exercise Other: Educational lectures Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Nitrite Levels and Vascular Function in Elderly Women Submitted to Water Exercise: a Randomised Controlled Trial
Study Start Date : May 2010
Actual Primary Completion Date : September 2010
Actual Study Completion Date : September 2010

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: Control Other: Educational lectures
Educational lectures

Experimental: Treatment Other: Exercise
The WG was submitted to a 16-week WEP, with combined aerobic and resistance exercises in three weekly sessions. Water temperature was approximately 30º C with an average ambient temperature of 34° C. The pool had water levels ranging between 1,20 and 1,40 meters deep.

Primary Outcome Measures :
  1. Determining modifications caused by this program on plasma nitrite concentration (NO3). [ Time Frame: 16 weeks ]
    For NO analysis, serum was separated from the erythrocyte mass. The material was centrifuged in a SIGMA 4k15 centrifuge at 3500 rpm and 18° for 10 minutes (LANEX laboratory- UFPI); the serum was then pipetted and frozen at 80° for evaluation after retesting (16 weeks). NO production was determined based on NO3 in the supernatant of cultured cells, an indirect measurement of NO synthesis.

Secondary Outcome Measures :
  1. Cerebral artery assessment [ Time Frame: 16 weeks ]
    Carotid and vertebral arteries were assessed by Doppler ultrasound, with GE Logiq 5 equipment and multi-frequency linear transducer (Milwaukee - UEA). Parameters used were evaluation of peak systolic velocity and end-diastolic velocity of the common carotid and left and right internal carotids, with the angle of insonation corrected to 60°. The resistivity index of arteries was calculated, resulting from the mathematical formula in centimeters per second (cm/s): Resistivity index = Peak systolic velocity - End-diastolic velocity / Peak systolic velocity.

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Ages Eligible for Study:   60 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • older than 60 and lass than 80 years age;
  • the elderly should be independent in their ADLs;
  • be considered able for medical evaluation to participate in the intervention and testing protocols;
  • still not be participating in regular systematized physical activity for at least six months.

Exclusion Criteria:

  • subjects with any form of transmittable or uncontrolled disease or insulin-dependent hypertensive;
  • unable to perform functional autonomy tests;
  • women undergo hormonal replacement therapy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01642654

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Universidade Estadual do Piauí
Teresina, PI, Brazil
Sponsors and Collaborators
Universidade Federal do Rio Grande do Norte
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Study Chair: Arméle Dornelas Universidade Federal de Pernambuco
Publications of Results:
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Responsible Party: Yula Pires da Silveira Fontenele de Meneses, Msc, Universidade Federal do Rio Grande do Norte Identifier: NCT01642654    
Other Study ID Numbers: yula01
First Posted: July 17, 2012    Key Record Dates
Last Update Posted: July 17, 2012
Last Verified: March 2012