Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis
|ClinicalTrials.gov Identifier: NCT01641705|
Recruitment Status : Unknown
Verified July 2012 by Alvaro Camilo Dias Faria, Hospital Universitario Pedro Ernesto.
Recruitment status was: Recruiting
First Posted : July 17, 2012
Last Update Posted : July 17, 2012
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by peripheral polyarthritis, symmetric, which leads to joint destruction and deformity. It is estimated that the RA reaches about 0.5% of the population. According to data from DATASUS, was responsible for 26,671 hospitalizations, 229 deaths and cost exceeding R$ 20 million in 2005-2007.
The main bodily changes are related to joint problems, however, systemic manifestations are also found in organs such as lung and heart. Although cardiovascular diseases are the most responsible of the deaths AR, pulmonary complications are common and account for 10% to 15% of all mortality. Anaya and colleagues point out that the pulmonary involvement contributes significant morbidity and mortality in these patients. Although pulmonary involvement is a frequent manifestation in RA, the prevalence and nature of rheumatoid lung disease has not yet been precisely established. Several lung disorders such as interstitial pulmonary fibrosis, pulmonary nodules and bronchiolitis may ocorrer1. Laitinen et al point out that studies of lung function appear to be a valuable helper for radiography in the evaluation of pulmonary involvement in connective tissue diseases. Previous studies indicate that patients with RA have an increased incidence of abnormal lung function, according to assessments including spirometry, lung volume tests and diffusion capacity of carbon monoxide.
Thus, the main objective of this study is to analyze the respiratory mechanics of patients with RA. Specific objectives were to seek to understand whether a relationship exists between duration of rheumatoid disease and lung function in these patients.
For this, the investigators used 18 subjects in the control group, free of pulmonary disease and / or heart, all nonsmokers. In the RA group, a total of 72 patients divided into 4 groups of 18 volunteers each, classified according to disease duration (0-5 years, 6-10 years, 11-15 years and> or = 16 years). It is noteworthy that all patients in the RA group will also be non-smokers, since it is already known in the literature that smoking impairs lung function. All individuals will perform the function test with a trained technician and qualified to function. The examinations will be conducted: Forced oscillation technique and spirometry, in that order.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||90 participants|
|Official Title:||Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis: Effect of Duration of Disease|
|Study Start Date :||July 2010|
|Estimated Primary Completion Date :||December 2012|
|Estimated Study Completion Date :||July 2013|
Group of nonsmokers individuals without respiratory disease.
RA patients 1
RA patients nonsmokers with up to five years of disease.
RA group 2
RA patients nonsmokers with six to ten years of disease.
RA group 3
RA patients nonsmokers with eleven to fifteen years of disease.
RA group 4
RA patients nonsmokers with sixteen or more years of disease
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01641705
|Contact: Alvaro Camilo D Faria||(5521)firstname.lastname@example.org|
|Laboratório de Instrumentação Biomédica||Recruiting|
|Rio de Janeiro, Brazil, 21550-013|
|Contact: Alvaro Camilo D Faria (5521)78201688 email@example.com|
|Principal Investigator: Alvaro Camilo D Faria|
|Principal Investigator: Pedro L de Melo|
|Principal Investigator: Geraldo Castelar|
|Principal Investigator: Agnaldo J Lopes|
|Study Director:||Pedro L de Melo||State University of Rio de Janeiro|