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Urine and Stool Analysis in Kidney Stone Disease

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2016 by University of British Columbia
Information provided by (Responsible Party):
University of British Columbia Identifier:
First received: December 13, 2011
Last updated: July 4, 2016
Last verified: July 2016
The purpose of this study is to add to the investigators' quest to understanding stone disease, by evaluating the metabolites excretion in urine and its relation to microflora present in the stool.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Correlation Between Excretion Metabolites in Urine and Bacterial Microflora in Patients With Urinary Stone Disease

Resource links provided by NLM:

Further study details as provided by University of British Columbia:

Primary Outcome Measures:
  • Bacterial flora in the intestine of patients with kidney stones compared to non-stone forming individuals [ Time Frame: one day of urine and stool collection ]
    The objective of this study is to compare the bacterial flora in the intestine of patients with kidney stones compared to non-stone forming individuals. If there are differences between stone forming and non-stone forming individuals in the content of their bacterial flora, these will also be correlated with levels of metabolites found in the urine that are known risk factors of stone disease. Difference in bacterial intestinal flora already exists for patients who are obese compared to non-obese individuals.

Biospecimen Retention:   Samples With DNA
De-identified and study coded urine and stool are collected, processed and analysed in the research laboratory.

Estimated Enrollment: 20
Study Start Date: July 2012
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
Study group
  • Age > 19
  • Radiological evidence indicating presence of a current renal or ureteric stone
Control group
  • Age > 19.
  • No history of kidney stone disease

Detailed Description:

Kidney stones affect up to 10% of the Canadian population and can lead to pain, hospitalization, lost of time at work, and surgery. Approximately 80% of stones consist of calcium and oxalate, of which both components come from diet and normal bodily processes. Individuals who have high levels of oxalate in their urine have a greater tendency to generate stones. One recommendation is to reduce their intake of oxalate-containing foods, but many healthy foods contain oxalate, and an oxalate-free diet is unpalatable and difficult to achieve. Some patients, despite reducing their oxalate intake, still have high amounts in the urine.

Intestinal metabolism is largely affected by the state and composition of the intestinal bacterial flora, with several metabolic diseases being linked to a disrupted "normal" intestinal flora. The investigators believe that calcium oxalate stone disease as well as high urinary levels of oxalate (hyperoxaluria) are triggered by inefficient oxalate metabolism in the intestine, which is linked to a "disrupted" intestinal bacterial flora that lacks certain key components such as O. formigenes. The long-term purpose of this study is therefore, to determine the effect of replenishing the intestinal flora of patients with that of "normal" controls, thereby re-introducing a balanced environment that will lead to the re-establishment of normal metabolic functions and a decrease in urinary oxalate levels and hopefully lower incidence of stone disease.


Ages Eligible for Study:   19 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Subjects in the study group are seen at Vancouver General Hospital for their kidney stone disease. Subjects in the control group do not have history or family history of kidney stones and can join the study if they are eligible, wiling to participate, and can provide their specimens at Vancouver General Hospital.

Inclusion Criteria:


  • Age > 19.
  • No history of kidney stone disease

STUDY (Stone Patient)

  • Age > 19
  • Radiological evidence indicating presence of a current renal or ureteric stone

Exclusion Criteria:

  • Pregnancy
  • Positive Urine Culture
  • Active cancer
  • Recurrent urinary infections
  • Gross hematuria
  • Inability to provide informed consent
  • In the Investigator's opinion, the patient would not be good for the study.


  • Family history of kidney stones
  • History of kidney stones
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01637506

Contact: Olga Arsovska, BSc 604-875-4111 ext 62421

Canada, British Columbia
Vancouver General Hospital Recruiting
Vancouver, British Columbia, Canada, V5Z 1M9
Contact: Olga Arsovska, BSc    604-875-4111 ext 62421   
Stone Centre, Vancouver General Hospital, Jim Pattison Pavilion Recruiting
Vancouver, British Columbia, Canada
Contact: Olga Arsovska, BSc    604-875-4111 ext 62421   
Principal Investigator: Ben Chew, MD,MSc,FRCSC         
Sponsors and Collaborators
University of British Columbia
Study Director: Dirk Lange, MSc, PhD University of British Columbia
Study Director: Ryan F Paterson, MD, FRCS(C) University of British Columbia
Study Director: Colin Collins, MA, CA, PhD Vancouver Coastal Health
Study Director: Stephane LeBihan, PhD Vancouver Prostate Centre
  More Information

Responsible Party: University of British Columbia Identifier: NCT01637506     History of Changes
Other Study ID Numbers: H10-01195
Study First Received: December 13, 2011
Last Updated: July 4, 2016

Keywords provided by University of British Columbia:
kidney stones

Additional relevant MeSH terms:
Urologic Diseases processed this record on May 23, 2017